Featured Research

from universities, journals, and other organizations

New technique advances bioprinting of cells

Date:
July 5, 2011
Source:
American Institute of Physics
Summary:
By extending pioneering acoustical work that applied sound waves to generate droplets from fluids, researchers have made encouraging preliminary findings at an early and crucial point in a stem cell's career known as embroid body formation.

Ever since an ordinary office inkjet printer had its ink cartridges swapped out for a cargo of cells about 10 years ago and sprayed out cell-packed droplets to create living tissue, scientists and engineers have never looked at office equipment in quite the same way. They dream of using a specialized bio-inkjet printer to grow new body parts for organ transplants or tissues for making regenerative medicine repairs to ailing bodies. Both these new therapies begin with a carefully printed mass of embryonic stem cells. And now there's progress on getting that initial mass of stem cells printed.

By extending his pioneering acoustical work that applied sound waves to generate droplets from fluids, Dr. Utkan Demirci and his team at Harvard Medical School's (Brigham and Women's Hospital) Bio-Acoustic Mems in Medicine Laboratory have made encouraging preliminary findings at an early and crucial point in a stem cell's career known as embroid body formation. Their research results appear in the journal Biomicrofluids, published by the American Institute of Physics.

Getting the embroid body formed correctly and without mechanical trauma is key to preserving the stem cells' astounding ability to develop into any desired tissue. Their new automated bioprinting approach appears to do this better than manual pipetting in the "hang-drop" method traditionally used.

Notes Dr. Demirci: "To have the capability to manipulate cells in a high-throughput environment reliably and repeatedly, whether it is a single cell or tens of thousands of cells in a single droplet, has the potential to enable potential solutions to many problems in medicine and engineering."

Three research results stand out:

  • Enhanced uniformity of size and ability to control droplet size. These are key variables because they determine how the embroid bodies will grow.
  • Achieving a scalable system that can print one cell or tens of thousands per droplet -- a level of precise manipulation not previously available.
  • Faster droplet formation. The new system delivers 160 droplets/seconds, versus 10 minutes for the hang-drop method.

The next step involves assessing the two methods to compare their effects on cell function. Says Dr. Demirci: "We are eager to take it to the next level."


Story Source:

The above story is based on materials provided by American Institute of Physics. Note: Materials may be edited for content and length.


Journal Reference:

  1. Feng Xu, BanuPriya Sridharan, ShuQi Wang, Umut Atakan Gurkan, Brian Syverud, Utkan Demirci. Embryonic stem cell bioprinting for uniform and controlled size embryoid body formation. Biomicrofluidics, 2011; 5 (2): 022207 DOI: 10.1063/1.3580752

Cite This Page:

American Institute of Physics. "New technique advances bioprinting of cells." ScienceDaily. ScienceDaily, 5 July 2011. <www.sciencedaily.com/releases/2011/07/110701121629.htm>.
American Institute of Physics. (2011, July 5). New technique advances bioprinting of cells. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2011/07/110701121629.htm
American Institute of Physics. "New technique advances bioprinting of cells." ScienceDaily. www.sciencedaily.com/releases/2011/07/110701121629.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins