Featured Research

from universities, journals, and other organizations

Biomarker MIA shows presence of neurofibromas

Date:
July 3, 2011
Source:
BioMed Central
Summary:
Neurofibromatosis (NF1) is a genetic condition which affects one in every 3,000 people. New research shows that a simple blood test for the protein melanoma-inhibitory activity (MIA) could be used to indicate the presence of neurofibromas even if they cannot be seen.

Neurofibromatosis (NF1) is a genetic condition which affects one in every 3,000 people. The severity of symptoms can range from benign 'cafι au lait' patches on the skin, through small tumors under the skin and deep plexiform neurofibromas, to malignant tumors of the nerve sheath. New research published in BioMed Central's open access journal BMC Medicine shows that a simple blood test for the protein melanoma-inhibitory activity (MIA) could be used to indicate the presence of neurofibromas even if they cannot be seen.

Related Articles


When researchers compared the levels of MIA from blood of patients with NF1 and unaffected controls they discovered that the patients with NF1 had much higher serum levels of MIA and that the level of MIA depended on the number and size of neurofibromas and plexiform neurofibromas the patient had. Tumor biopsies also showed an increase in MIA at the cellular level.

Dr Kolanczyk said, "Using the biomarker MIA to test for the presence and growth of plexiform neurofibromas would be an easier and cheaper way of monitoring clinical course of the patients and would allow the early detection of tumors so improving the treatment, management and outcome. Detection of deep plexiform neurofibroma is currently only possible using MRI scan and since these tumors can become malignant it is important to monitor their growth closely and detect signs of malignant transformation as early as possible."


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mateusz Kolanczyk, Victor Mautner, Nadine Kossler, Rosa Nguyen, Jirko Kόhnisch, Tomasz Zemojtel, Aleksander Jamsheer, Eike Wegener, Boris Thurisch, Sigrid Tinschert, Nikola Holtkamp, Su-Jin Park, Patricia Birch, David Kendler, Anja Harder, Stefan Mundlos and Lan Kluwe. MIA is a potential biomarker for tumor load in neurofibromatosis type 1. BMC Medicine, 2011; 9: 82 DOI: 10.1186/1741-7015-9-82

Cite This Page:

BioMed Central. "Biomarker MIA shows presence of neurofibromas." ScienceDaily. ScienceDaily, 3 July 2011. <www.sciencedaily.com/releases/2011/07/110703222941.htm>.
BioMed Central. (2011, July 3). Biomarker MIA shows presence of neurofibromas. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2011/07/110703222941.htm
BioMed Central. "Biomarker MIA shows presence of neurofibromas." ScienceDaily. www.sciencedaily.com/releases/2011/07/110703222941.htm (accessed February 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, February 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) — A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) — An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) — A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) — If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins