Featured Research

from universities, journals, and other organizations

Indirubin, component Of Chinese herbal remedy, might block brain tumor's spread, study suggests

Date:
July 12, 2011
Source:
Ohio State University Medical Center
Summary:
Indirubin, the active ingredient in a traditional Chinese herbal medicine, might offer a new strategy for treating glioblastoma, a deadly form of brain cancer. A new study shows that indirubin both blocks the migration of glioblastoma cells, preventing their spread to other areas of the brain, and the migration of endothelial cells, preventing them from forming the new blood vessels the tumor needs to grow.

The active ingredient in a traditional Chinese herbal remedy might help treat deadly brain tumors, according to a new study by researchers at the Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC -- James).

Related Articles


The researchers discovered that the compound, indirubin, both blocks the migration of glioblastoma cells, preventing their spread to other areas of the brain, and the migration of endothelial cells, preventing them from forming the new blood vessels that the tumor needs to grow.

Glioblastomas occur in about 18,500 Americans annually and kill nearly 13,000 of them yearly. Glioblastoma multiforme is the most common and lethal form of the malignancy, with an average survival of 15 months after diagnosis.

The research is published online in the journal Cancer Research.

"We have pretty good methods to stop glioblastoma from growing in the human brain, but these therapies fail because tumor cells migrate from the original site and grow elsewhere in the brain," says co-principal investigator Dr. E. Antonio Chiocca, professor and chair of neurological surgery and co-director of the Dardinger Center for Neuro-oncology and Neurosciences.

"Our findings suggest that indirubins offer a novel therapeutic strategy for these tumors that simultaneously targets tumor invasion and angiogenesis," Chiocca says.

"This study shows for the first time that drugs of the indirubin family may improve survival in glioblastoma, and that these agents inhibit two of the most important hallmarks of this malignancy -- tumor-cell invasion and angiogenesis," says co-principal investigator Dr. Sean Lawler, senior scientist and group leader of the Translational Neurooncology Group at the Leeds Institute of Molecular Medicine.

Indirubin is derived from the Indigo plant. It is the active ingredient in the Chinese herbal remedy called Dang Gui Long Hui Wan, which is used to treat chronic myeloid leukemia.

Chiocca, Lawler and their collaborators used multiple glioblastoma cell lines and two animal models to examine three derivatives of indirubin. Key findings include the following:

  • When human glioblastoma cells were transplanted into one brain hemisphere of mice, indirubin-treated animals survived significantly longer than controls and showed no migration of tumor cells to the opposite hemisphere.
  • In a separate experiment, indirubin reduced the migration of tumor cells by 40 percent in treated animals versus controls.
  • Treated tumors showed a lower density of blood vessels, and new blood-vessel growth was reduced up to three-fold in intracranial tumors, depending on the tumor-cell line.
  • A laboratory assay showed that indirubins reduced endothelial-cell migration by 52 to 41 percent compared with untreated controls.

"Overall, our findings suggest that indirubins reduce tumor invasion and tumor vasculature because of their antimigratory effects on both tumor and endothelial cells," Chiocca says.


Story Source:

The above story is based on materials provided by Ohio State University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. P. Williams, M. O. Nowicki, F. Liu, R. Press, J. Godlewski, M. Abdel-Rasoul, B. Kaur, S. A. Fernandez, E. A. Chiocca, S. E. Lawler. Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell compartments. Cancer Research, 2011; DOI: 10.1158/0008-5472.CAN-10-3026

Cite This Page:

Ohio State University Medical Center. "Indirubin, component Of Chinese herbal remedy, might block brain tumor's spread, study suggests." ScienceDaily. ScienceDaily, 12 July 2011. <www.sciencedaily.com/releases/2011/07/110712143006.htm>.
Ohio State University Medical Center. (2011, July 12). Indirubin, component Of Chinese herbal remedy, might block brain tumor's spread, study suggests. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2011/07/110712143006.htm
Ohio State University Medical Center. "Indirubin, component Of Chinese herbal remedy, might block brain tumor's spread, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/07/110712143006.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins