Featured Research

from universities, journals, and other organizations

'IDOLizing' low cholesterol

Date:
July 18, 2011
Source:
Journal of Clinical Investigation
Summary:
High levels of "bad" cholesterol (LDL cholesterol) are a risk factor for developing a disease of the major arterial blood vessels that is one of the major causes of heart attack and stroke. New human genetic and mechanistic studies have now identified the protein MYLIP (also known as IDOL) as a potential new target for an LDL cholesterol-lowering therapeutic.

High levels of 'bad' cholesterol (LDL cholesterol) are a risk factor for developing atherosclerotic cardiovascular disease (ASCVD) -- a disease of the major arterial blood vessels that is one of the major causes of heart attack and stroke. Although the use of statins and the adoption of lifestyle changes to reduce LDL cholesterol levels have decreased the incidence of and mortality from ASCVD, many individuals fail to reach target levels of LDL cholesterol.

Related Articles


Researchers are therefore seeking new targets for LDL cholesterol-lowering therapeutics.

Human genetic and mechanistic studies by a team of researchers, led by Päivi Pajukanta, at the David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, has now identified the protein MYLIP (also known as IDOL) as a potential new target in this context.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Daphna Weissglas-Volkov, Anna C. Calkin, Teresa Tusie-Luna, Janet S. Sinsheimer, Noam Zelcer, Laura Riba, Ana Maria Vargas Tino, Maria Luisa Ordoñez-Sánchez, Ivette Cruz-Bautista, Carlos A. Aguilar-Salinas, Peter Tontonoz, Päivi Pajukanta. The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI45504

Cite This Page:

Journal of Clinical Investigation. "'IDOLizing' low cholesterol." ScienceDaily. ScienceDaily, 18 July 2011. <www.sciencedaily.com/releases/2011/07/110718121546.htm>.
Journal of Clinical Investigation. (2011, July 18). 'IDOLizing' low cholesterol. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2011/07/110718121546.htm
Journal of Clinical Investigation. "'IDOLizing' low cholesterol." ScienceDaily. www.sciencedaily.com/releases/2011/07/110718121546.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) — A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins