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'IDOLizing' low cholesterol

Date:
July 18, 2011
Source:
Journal of Clinical Investigation
Summary:
High levels of "bad" cholesterol (LDL cholesterol) are a risk factor for developing a disease of the major arterial blood vessels that is one of the major causes of heart attack and stroke. New human genetic and mechanistic studies have now identified the protein MYLIP (also known as IDOL) as a potential new target for an LDL cholesterol-lowering therapeutic.

High levels of 'bad' cholesterol (LDL cholesterol) are a risk factor for developing atherosclerotic cardiovascular disease (ASCVD) -- a disease of the major arterial blood vessels that is one of the major causes of heart attack and stroke. Although the use of statins and the adoption of lifestyle changes to reduce LDL cholesterol levels have decreased the incidence of and mortality from ASCVD, many individuals fail to reach target levels of LDL cholesterol.

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Researchers are therefore seeking new targets for LDL cholesterol-lowering therapeutics.

Human genetic and mechanistic studies by a team of researchers, led by Päivi Pajukanta, at the David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, has now identified the protein MYLIP (also known as IDOL) as a potential new target in this context.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Daphna Weissglas-Volkov, Anna C. Calkin, Teresa Tusie-Luna, Janet S. Sinsheimer, Noam Zelcer, Laura Riba, Ana Maria Vargas Tino, Maria Luisa Ordoñez-Sánchez, Ivette Cruz-Bautista, Carlos A. Aguilar-Salinas, Peter Tontonoz, Päivi Pajukanta. The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI45504

Cite This Page:

Journal of Clinical Investigation. "'IDOLizing' low cholesterol." ScienceDaily. ScienceDaily, 18 July 2011. <www.sciencedaily.com/releases/2011/07/110718121546.htm>.
Journal of Clinical Investigation. (2011, July 18). 'IDOLizing' low cholesterol. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2011/07/110718121546.htm
Journal of Clinical Investigation. "'IDOLizing' low cholesterol." ScienceDaily. www.sciencedaily.com/releases/2011/07/110718121546.htm (accessed December 18, 2014).

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