Featured Research

from universities, journals, and other organizations

Research illuminating long-term non-progression suggests novel vaccination strategy for HIV

Date:
July 18, 2011
Source:
American Society for Microbiology
Summary:
A major problem researchers have faced in attempting to develop a vaccine for HIV is that the virus mutates incredibly quickly, which means that its antigens -- the target molecules of a vaccine -- are moving targets. A comparison of individuals who are able to control HIV without antiretroviral medication with those who are unable to do so suggests that a novel approach to vaccination might work around this problem.

A major problem researchers have faced in attempting to develop a vaccine for HIV is that the virus mutates incredibly quickly, which means that its antigens -- the target molecules of a vaccine -- are moving targets. A comparison of individuals who are able to control HIV without antiretroviral medication with those who are unable to do so suggests that a novel approach to vaccination might work around this problem. The research is published in the July Journal of Virology.

Related Articles


Human DNA contains so-called human endogenous retroviruses (HERVs), which are remnants of ancient retroviruses -- genetic fossils -- that under normal circumstances sit silently, and always genetically stably, within human DNA. In earlier work, a team of researchers led by Douglas Nixon of the University of California, San Francisco, showed that infection with HIV activates HERVs that lie inside HIV-infected cells in some individuals (but not those in non-infected cells), by interfering with regulatory compounds that normally prevent expression of these HERVs. The activated HERVs produce proteins that attract immune system T cells to the HIV-infected cells, targeting them for destruction. The researchers also showed that the greater T cell response, the lower an individual's viral load.

In the new research, Devi SenGupta of the University of California, San Francisco et al. extended these findings to include individuals who have long-term chronic HIV-1 infection. They compared the responses of a tiny subset of individuals who are unique in their ability to suppress the virus indefinitely without the aid of combination therapy to those of patients on highly active antiretroviral therapy (HAART), virologic noncontrollers, immunologic progressors, and uninfected controls. A strong anti-HERV response corresponded to a lower viral load, and a higher CD4+ T cell count. "Interestingly, controllers who lack HLA alleles [critical immune system components] that are associated with protection from HIV-1 disease progression… constituted a large proportion of the subjects with the strongest HERV responses, suggesting that there may be an alternative mechanism of HIV control (such as HERV-specific cytotoxic T cells) in these controllers," the researchers write.

The findings suggest that a vaccination targeting proteins produced by the HERV genes could help the immune system keep HIV in check, says SenGupta. "Our research helps lay the groundwork for developing a new therapeutic or preventive vaccine against HIV. If this leads to a new anti-HIV therapy, millions of lives could be improved all over the world."


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. SenGupta, R. Tandon, R. G. S. Vieira, L. C. Ndhlovu, R. Lown-Hecht, C. E. Ormsby, L. Loh, R. B. Jones, K. E. Garrison, J. N. Martin, V. A. York, G. Spotts, G. Reyes-Teran, M. A. Ostrowski, F. M. Hecht, S. G. Deeks, D. F. Nixon. Strong Human Endogenous Retrovirus-Specific T Cell Responses Are Associated with Control of HIV-1 in Chronic Infection. Journal of Virology, 2011; 85 (14): 6977 DOI: 10.1128/JVI.00179-11

Cite This Page:

American Society for Microbiology. "Research illuminating long-term non-progression suggests novel vaccination strategy for HIV." ScienceDaily. ScienceDaily, 18 July 2011. <www.sciencedaily.com/releases/2011/07/110718154800.htm>.
American Society for Microbiology. (2011, July 18). Research illuminating long-term non-progression suggests novel vaccination strategy for HIV. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2011/07/110718154800.htm
American Society for Microbiology. "Research illuminating long-term non-progression suggests novel vaccination strategy for HIV." ScienceDaily. www.sciencedaily.com/releases/2011/07/110718154800.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins