Featured Research

from universities, journals, and other organizations

HIV therapies provide near normal lifespan in Africa, study shows

Date:
July 19, 2011
Source:
University of British Columbia
Summary:
The first large-scale analysis of life expectancy outcomes in Africa for HIV patients receiving combination antiretroviral therapy (cART) shows that such patients can expect to live a near normal lifespan. The study also shows significant variance between patient subgroups.

A landmark study by the BC Centre for Excellence in HIV/AIDS (BC-CfE) and the University of British Columbia (UBC) shows that patients in Africa receiving combination antiretroviral therapy (cART) for HIV can expect to live a near normal lifespan.

The study, published in the Annals of Internal Medicine, is the first large-scale analysis of life expectancy outcomes in Africa for HIV patients on cART and shows significant variance between patient subgroups. Females have a significantly higher life expectancy than men, and in all participants, early initiation of treatment was associated with longer life expectancy.

"The substantial life expectancy afforded by widespread access to cART underscores the fact that HIV diagnosis and treatment in resource-limited settings should no longer be considered a death sentence," said principal investigator Dr. Edward Mills, associate researcher at the BC-CfE and an adjunct professor in UBC's Faculty of Medicine. "Instead, HIV-infected people should plan and prepare for a long and fulfilling life."

The authors believe that the study, conducted in Uganda, reflects the situation in many other settings in Africa, where simplified HIV/AIDS care in rural, semi-rural and urban settings is available.

"Our findings are further evidence that the global investment in HIV and AIDS programming is clearly working," said Dr. Mark Dybul, a study author who led the implementation of the multibillion-dollar U.S. President's Emergency Plan for AIDS Relief (PEPFAR) from 2006-2009 and is now at Georgetown University and the George W. Bush Institute. "Healthcare organizations -- even in resource-poor settings -- are providing services and therapies that offer important, life-saving benefits to people suffering from HIV."

The study analyzed a cohort of 22,315 individuals aged 14 or older, who initiated cART at The AIDS Support Organization (TASO) clinics between 2000 and 2009. In Uganda, life expectancy at birth is approximately 55 years and increases as individuals survive key milestones. Life expectancy at age 20 years for the overall study cohort on cART was an additional 26.7 years and at age 35 an additional 27.9 years.

Males showed consistently lower life expectancy than females. Life expectancy at age 20 years was 19.1 years for males and 30.6 years for females, and at age 35 years was 22 years for males and 32.5 years for females. Men typically access care at a later stage, with more advanced disease, and have higher rates of mortality than females. "Men remain one of our huge challenges in terms of access to clinical services," said Mills.

The study found a strong association between baseline CD4 cell status and mortality when controlling for factors such as age, year of cART initiation and gender. Those who started cART earlier, at a higher CD4 cell status, lived longer.

"These benefits will only be sustained if there is continued support for cART scale up by the international donor community and national governments," said study author Dr. Jean Nachega, Professor of Medicine and director of the Centre for Infectious Diseases at Stellenbosch University, Cape Town, South Africa. "We require sustainable investment and simplified treatment options to deliver long-term care and access more people in Africa with HIV."

Although more than 200,000 patients are receiving cART in Uganda, about 200,000 more Ugandans await cART initiation.

The study findings also support the Treatment as Prevention strategy pioneered at the BC-CfE and adopted by the Joint United Nations Programme on HIV/AIDS (UNAIDS) as a key pillar of its Treatment 2.0 initiative, the cornerstone of the so called "Prevention Revolution." Treatment as Prevention calls for widespread HIV testing and early treatment for all medically eligible individuals to prevent disease progression and death and to prevent HIV transmission. Treatment as Prevention could be an effective component of combination prevention strategies.

The study was funded by the Canadian Institutes of Health Research.


Story Source:

The above story is based on materials provided by University of British Columbia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Edward J. Mills, Celestin Bakanda, Josephine Birungi, Keith Chan, Nathan Ford, Curtis L. Cooper, Jean B. Nachega, Mark Dybul, Robert S. Hogg. Life Expectancy of Persons Receiving Combination Antiretroviral Therapy in Low-Income Countries: A Cohort Analysis From Uganda. Annals of Internal Medicine, 2011; E-358 DOI: 10.1059/0003-4819-155-4-201108160-00358

Cite This Page:

University of British Columbia. "HIV therapies provide near normal lifespan in Africa, study shows." ScienceDaily. ScienceDaily, 19 July 2011. <www.sciencedaily.com/releases/2011/07/110718182811.htm>.
University of British Columbia. (2011, July 19). HIV therapies provide near normal lifespan in Africa, study shows. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2011/07/110718182811.htm
University of British Columbia. "HIV therapies provide near normal lifespan in Africa, study shows." ScienceDaily. www.sciencedaily.com/releases/2011/07/110718182811.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins