Featured Research

from universities, journals, and other organizations

One species of pathogen can produce two distinct biofilms

Date:
August 3, 2011
Source:
Public Library of Science
Summary:
Many medical devices, ranging from artificial hip joints to dentures and catheters, can come with unwelcome guests -- complex communities of microbial pathogens called biofilms that are resistant to the human immune system and antibiotics, thus proving a serious threat to human health. However, researchers may have a new way of looking at biofilms, thanks to a new study.

Many medical devices, ranging from artificial hip joints to dentures and catheters, can come with unwelcome guests -- complex communities of microbial pathogens called biofilms that are resistant to the human immune system and antibiotics, thus proving a serious threat to human health. However, researchers may have a new way of looking at biofilms, thanks to a study conducted by University of Iowa biologist David Soll and his colleagues published in the Aug 2 issue of the online, open access journal PLoS Biology.

Previously, researchers believed that each pathogen formed one kind of biofilm, but Soll and his colleagues have discovered that the pernicious fungal pathogen Candida albicans makes two kinds of biofilms; a traditional pathogenic one, and a second sexual one. This discovery provides new and profound insights into developing new therapies that target pathogenic biofilms for disruption.

Soll and his colleagues showed for the first time that the majority -- about 90 percent -- of cells colonizing humans make a pathogenic biofilm that cannot be penetrated by antifungal agents, antibodies or white blood cells. These majority cells are sexually incompetent. But a minority -- about 10 percent -- of cells, which are sexually competent, form highly permeable and penetrable biofilms, which Soll and his colleagues have shown act as a supportive environment for mating. They demonstrate that although the pathogenic and sexual biofilms appear macroscopically similar, they are regulated by entirely different signalling pathways.

"Having two outwardly similar, but functionally different, biofilms provides us with one means of finding out what makes the pathogenic biofilm resistant to all challenges, and the sexual biofilm non-resistant," Soll said. "Whatever that difference is will represent a major target for future drug discovery."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Song Yi, Nidhi Sahni, Karla J. Daniels, Kevin L. Lu, Thyagarajan Srikantha, Guanghua Huang, Adam M. Garnaas, David R. Soll. Alternative Mating Type Configurations (a/α versus a/a or α/α) of Candida albicans Result in Alternative Biofilms Regulated by Different Pathways. PLoS Biology, 2011; 9 (8): e1001117 DOI: 10.1371/journal.pbio.1001117

Cite This Page:

Public Library of Science. "One species of pathogen can produce two distinct biofilms." ScienceDaily. ScienceDaily, 3 August 2011. <www.sciencedaily.com/releases/2011/08/110802180818.htm>.
Public Library of Science. (2011, August 3). One species of pathogen can produce two distinct biofilms. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2011/08/110802180818.htm
Public Library of Science. "One species of pathogen can produce two distinct biofilms." ScienceDaily. www.sciencedaily.com/releases/2011/08/110802180818.htm (accessed April 17, 2014).

Share This



More Plants & Animals News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Great British Farmland Boom

The Great British Farmland Boom

Reuters - Business Video Online (Apr. 17, 2014) Britain's troubled Co-operative Group is preparing to cash in on nearly 18,000 acres of farmland in one of the biggest UK land sales in decades. As Ivor Bennett reports, the market timing couldn't be better, with farmland prices soaring over 270 percent in the last 10 years. Video provided by Reuters
Powered by NewsLook.com
Change of Diet Helps Crocodile Business

Change of Diet Helps Crocodile Business

Reuters - Business Video Online (Apr. 16, 2014) Crocodile farming has been a challenge in Zimbabwe in recent years do the economic collapse and the financial crisis. But as Ciara Sutton reports one of Europe's biggest suppliers of skins to the luxury market has come up with an unusual survival strategy - vegetarian food. Video provided by Reuters
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins