Featured Research

from universities, journals, and other organizations

Human-made fat may limit damage to heart attack victims

Date:
August 5, 2011
Source:
University of California - Los Angeles Health Sciences
Summary:
A human-made fat called Intralipid, which is currently used as a component of intravenous nutrition and to treat rare overdoses of local anesthetics, may also offer protection for patients suffering from heart attacks.

A human-made fat called Intralipid, which is currently used as a component of intravenous nutrition and to treat rare overdoses of local anesthetics, may also offer protection for patients suffering from heart attacks.

Related Articles


Current treatment for a heart attack focuses on limiting the duration of the ischemic period, when blood flow to tissues is reduced, and on subsequently opening arteries to reestablish normal coronary blood flow. It is well known that injury to the heart muscle can occur after oxygen and nutrients in the blood flow back to deprived cells, a phenomenon known as reperfusion injury, and scientists have been seeking ways to minimize such injury.

A UCLA preclinical study identified how Intralipid -- a fat emulsion made up of a combination of soy bean oil, egg phospholipids and glycerin that provides essential fatty acids -- can prevent extensive heart damage and help preserve heart function when used during the return of blood flow to the heart immediately following a heart attack.

This research shows that intralipid may help cell integrity and function when the body is under stress, such as during a heart attack, thus introducing a new way to significantly decrease damage to the heart muscle due to reperfusion injury or to prolong the tolerance of a tissue or an organ to lack of oxygen.

The findings may have implications for future therapies. The technique is not limited to the heart, researchers say, and could potentially be used for any ischemic organs suffering a blockage in blood flow or for organs used for transplant.

The lead study author was Dr. Siamak Rahman, an associate professor of anesthesiology at the David Geffen School of Medicine at UCLA.


Story Source:

The above story is based on materials provided by University of California - Los Angeles Health Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Siamak Rahman, Jingyuan Li, Jean Chrisostome Bopassa, Soban Umar, Andrea Iorga, Parisa Partownavid, Mansoureh Eghbali. Phosphorylation of GSK-3β Mediates Intralipid-induced Cardioprotection against Ischemia/Reperfusion Injury. Anesthesiology, 2011; 115 (2): 242 DOI: 10.1097/ALN.0b013e318223b8b9

Cite This Page:

University of California - Los Angeles Health Sciences. "Human-made fat may limit damage to heart attack victims." ScienceDaily. ScienceDaily, 5 August 2011. <www.sciencedaily.com/releases/2011/08/110805135756.htm>.
University of California - Los Angeles Health Sciences. (2011, August 5). Human-made fat may limit damage to heart attack victims. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2011/08/110805135756.htm
University of California - Los Angeles Health Sciences. "Human-made fat may limit damage to heart attack victims." ScienceDaily. www.sciencedaily.com/releases/2011/08/110805135756.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins