Featured Research

from universities, journals, and other organizations

Frequent mutations of chromatin remodeling genes discovered in transitional cell carcinoma of the bladder

Date:
August 7, 2011
Source:
Beijing Genomics Institute
Summary:
New research provides a valuable genetic basis for future studies on transitional cell carcinoma, suggesting that aberration of chromatin regulation might be one of the features of bladder cancer.

BGI, the world's largest genomics organization, Peking University Shenzhen Hospital and Shenzhen Second People's Hospital, announced on August 7 that the study on frequent mutations of chromatin remodeling genes in transitional cell carcinoma (TCC) of the bladder was published online in Nature Genetics. This study provides a valuable genetic basis for future studies on TCC, suggesting that aberration of chromatin regulation might be one of the features of bladder cancer.

Bladder cancer is the ninth most common type of cancer worldwide, which affects three times as many men as women. Almost all bladder cancers originate in the urothelium, so they are also known as one of the most common tumors of the genitourinary tract. Each year, about 360,000 new cases of bladder cancer are expected, and about 150,000 people will die of this disease in the world. In North America, South America, Europe, and Asia, TCC is the most common type of bladder cancer diagnosed, accounting for 90% of all bladder malignancies in those regions.

"Considering the high risks of TCC and the lack of comprehensive analysis, we and our partners initiated this project to identify other previously unidentified genes associated with the bladder cancer." said Professor Zhiming Cai, President of Shenzhen Second People's Hospital and the former President of Peking University Shenzhen Hospital. "I hope our unexpected discoveries in this study can provide more important insights into potential diagnoses and the therapeutic applications." he added.

In this study, the exomes of nine patients with TCC were sequenced with BGI's exome sequencing platform. Then, all the somatically mutated genes were screened in a prevalence set of 88 additional patients with TCC at different tumor stages and grades. "After the detections and statistical analysis, we discovered 49 new significantly mutated genes associated with TCC, and these genes are previously unknown to be mutated in TCC." said Professor Yaoting Gui,the co-leading author of the study and Vice-Director of the Institute of Urology at Peking University Shenzhen Hospital, "Another interesting finding is that eight genes among them are associated with chromatin remodeling, which could be related with frequent mutations in the majority of TCCs."

"We identified the genetic aberrations of the chromatin remodeling genes in 59% of the 97 individuals with TCC, and discovered one gene, UTX, could be altered substantially more frequently in tumors with low stages and grades." said Guangwu Guo, one of the co-leading authors of the study and PI of this project at BGI. "This study indicates UTX may pose a potential role in the classification and diagnosis of bladder cancer."

As we all know, aberrations of the chromatin remodeling genes may directly lead to the misregulation of multiple downstream effector genes, consequently promoting the tumor genesis process. "In our study, the newly discovered genetic mutations in the chromatin remodeling genes, except for UTX, are previous unknown in the primary tumors of TCC." said professor Cai. "Our results demonstrate that the disruption of the chromatin remodeling machinery may be one of the main mechanisms that lead to TCC."

Professor Jun Wang, Executive Director of BGI, said, "This study provides further understanding of bladder cancer and other human cancers through the comprehensive analysis of genetic alterations in TCC. It also implicates the necessity to enhance the epigenomics research in the field of cancer studies in the future. "


Story Source:

The above story is based on materials provided by Beijing Genomics Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yaoting Gui, Guangwu Guo, Yi Huang, Xueda Hu, Aifa Tang, Shengjie Gao, Renhua Wu, Chao Chen, Xianxin Li, Liang Zhou, Minghui He, Zesong Li, Xiaojuan Sun, Wenlong Jia, Jinnong Chen, Shangming Yang, Fangjian Zhou, Xiaokun Zhao, Shengqing Wan, Rui Ye, Chaozhao Liang, Zhisheng Liu, Peide Huang, Chunxiao Liu, Hui Jiang, Yong Wang, Hancheng Zheng, Liang Sun, Xingwang Liu, Zhimao Jiang, Dafei Feng, Jing Chen, Song Wu, Jing Zou, Zhongfu Zhang, Ruilin Yang, Jun Zhao, Congjie Xu, Weihua Yin, Zhichen Guan, Jiongxian Ye, Hong Zhang, Jingxiang Li, Karsten Kristiansen, Michael L Nickerson, Dan Theodorescu, Yingrui Li, Xiuqing Zhang, Songgang Li, Jian Wang, Huanming Yang, Jun Wang, Zhiming Cai. Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nature Genetics, 2011; DOI: 10.1038/ng.907

Cite This Page:

Beijing Genomics Institute. "Frequent mutations of chromatin remodeling genes discovered in transitional cell carcinoma of the bladder." ScienceDaily. ScienceDaily, 7 August 2011. <www.sciencedaily.com/releases/2011/08/110807143901.htm>.
Beijing Genomics Institute. (2011, August 7). Frequent mutations of chromatin remodeling genes discovered in transitional cell carcinoma of the bladder. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2011/08/110807143901.htm
Beijing Genomics Institute. "Frequent mutations of chromatin remodeling genes discovered in transitional cell carcinoma of the bladder." ScienceDaily. www.sciencedaily.com/releases/2011/08/110807143901.htm (accessed July 26, 2014).

Share This




More Health & Medicine News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins