Featured Research

from universities, journals, and other organizations

New experimental vaccine against chikungunya virus created

Date:
August 14, 2011
Source:
University of Texas Medical Branch at Galveston
Summary:
Researchers have developed a new candidate vaccine to protect against chikungunya virus, a mosquito-borne pathogen that produces an intensely painful and often chronic arthritic disease that has stricken millions of people in India, Southeast Asia and Africa.

Researchers have developed a new candidate vaccine to protect against chikungunya virus, a mosquito-borne pathogen that produces an intensely painful and often chronic arthritic disease that has stricken millions of people in India, Southeast Asia and Africa.

A single dose of the experimental vaccine protected lab mice from infection with the virus, according to a paper published online in the journal PLoS Pathogens by researchers from the University of Texas Medical Branch at Galveston, Inviragen, Inc., of Ft. Collins, Colorado, the University of Wisconsin, the Centers for Disease Control and Prevention and the University of Alabama.

"Currently, we have no approved treatment or vaccine for chikungunya, and there's a real need for an effective vaccine to protect against this debilitating and economically devastating infection," said Scott Weaver, director of UTMB's Institute for Human Infections and Immunity, scientific director of the Galveston National Laboratory and senior author of the paper. "Everything we've seen so far suggests this vaccine candidate could fill that need."

The experimental vaccine is a "recombinant live-attenuated vaccine" created by genetically modifying the chikungunya virus using techniques developed with the initial support from the Western Regional Center of Excellence in Biodefense and Emerging Infectious Diseases, headquartered at UTMB. The resulting vaccine strain differs from wild-type chikungunya virus in two ways: it doesn't cause disease, and it's incapable of infecting mosquitoes; the latter trait is an important safety feature to ensure that the vaccine strain cannot initiate transmission in nonendemic locations where travelers might be immunized before a trip to Africa or Asia. But it still provokes an immune response to protect against future chikungunya infections.

Such a live virus vaccine would also be relatively economical to produce in large quantities -- an important factor given the limited resources available in the areas hit hardest by chikungunya.

"We need to slow this virus down in India and Southeast Asia, not just to protect the people there but to reduce the very real risk that it might become endemic here after an infected traveler arrives," Weaver said. "The best way to do that is with a vaccine, and if you're going to make a vaccine you have to look at where it's going to be used and what they can afford."

UTMB has signed a license agreement with Inviragen for commercialization of the new vaccine candidate. In addition, the two partners have been chosen to receive a four-year, $3 million grant from the National Institutes of Health to complete the preclinical development work needed submit an investigational new drug application to the Food and Drug Administration, opening the door to human trials.


Story Source:

The above story is based on materials provided by University of Texas Medical Branch at Galveston. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kenneth Plante, Eryu Wang, Charalambos D. Partidos, James Weger, Rodion Gorchakov, Konstantin Tsetsarkin, Erin M. Borland, Ann M. Powers, Robert Seymour, Dan T. Stinchcomb, Jorge E. Osorio, Ilya Frolov, Scott C. Weaver. Novel Chikungunya Vaccine Candidate with an IRES-Based Attenuation and Host Range Alteration Mechanism. PLoS Pathogens, 2011; 7 (7): e1002142 DOI: 10.1371/journal.ppat.1002142

Cite This Page:

University of Texas Medical Branch at Galveston. "New experimental vaccine against chikungunya virus created." ScienceDaily. ScienceDaily, 14 August 2011. <www.sciencedaily.com/releases/2011/08/110812120923.htm>.
University of Texas Medical Branch at Galveston. (2011, August 14). New experimental vaccine against chikungunya virus created. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2011/08/110812120923.htm
University of Texas Medical Branch at Galveston. "New experimental vaccine against chikungunya virus created." ScienceDaily. www.sciencedaily.com/releases/2011/08/110812120923.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
WHO: Ebola Cases to Triple in Weeks Without Drastic Action

WHO: Ebola Cases to Triple in Weeks Without Drastic Action

AFP (Sep. 23, 2014) The number of Ebola infections will triple to 20,000 by November, soaring by thousands every week if efforts to stop the outbreak are not stepped up radically, the WHO warned in a study on Tuesday. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
5 Ways Men Can Prevent Most Heart Attacks

5 Ways Men Can Prevent Most Heart Attacks

Newsy (Sep. 23, 2014) No surprise here: A recent study says men can reduce their risk of heart attack by maintaining a healthy lifestyle, which includes daily exercise. Video provided by Newsy
Powered by NewsLook.com
Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins