Featured Research

from universities, journals, and other organizations

Stem cell study offers hope for Parkinson's patients

Date:
August 23, 2011
Source:
University of Edinburgh
Summary:
Scientists have for the first time generated stem cells from one of the most rapidly progressing forms of Parkinson's disease. The development will help research into the condition as it will enable scientists to model the disease in the laboratory to shed light on why certain nerve cells die.

Scientists have for the first time generated stem cells from one of the most rapidly progressing forms of Parkinson's disease.

The development will help research into the condition as it will enable scientists to model the disease in the laboratory to shed light on why certain nerve cells die.

Scientists, funded with a 300,000 grant from the charity Parkinson's UK, took skin samples from a patient diagnosed with one of the most progressive types of Parkinson's.

The research, led by the University of Edinburgh in collaboration with UCL (University College London), then used these skin cells to generate brain nerve cells affected by the disease.

The ability to generate these nerve cells will make it easier to monitor the effectiveness of potential new drugs that could slow or halt progress of the condition.

The aim would be to find drugs that can prevent the death of these key cells -- known as neurons -- which break down as a result of Parkinson's.

Dr Tilo Kunath, of the University of Edinburgh's Medical Research Council Centre for Regenerative Medicine, said: "Current drugs for Parkinson's alleviate symptoms of the condition. Modelling the disease in a dish with real Parkinson's neurons enables us to test drugs that may halt or reverse the condition.

"This study provides an ideal platform to gain fresh insight into the condition, and opens a new area of research to discover disease-modifying drugs."

The neuron cells were generated from a patient with a form of Parkinson's that progresses rapidly and can be diagnosed in people in their early 30s.

People with this form of Parkinson's have twice as many of the genes that produce a protein -- alpha synuclein -- compared with the general population.

Although this form of Parkinson's is rare the protein involved is linked to virtually all types of the disease.

Dr Michael Devine, of the UCL Institute of Neurology said, "Understanding such a progressive form of the disease will give us insight into different types of Parkinson's. As this type of Parkinson's progresses rapidly it will also make it easier to pick up the effects of drugs tested to prevent nerve cells targeted by the disease from dying."

The research was published in the journal Nature Communications.

Dr Kieran Breen, Director of Research and Development at Parkinson's UK, said: "Although the genetic mutation that leads to this progressive form of Parkinson's is rare this exciting study has the potential to bring about a huge breakthrough in Parkinson's research.

"This is just the kind of innovative research that Parkinson's UK is committed to funding as we move closer to a cure."


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michael J. Devine, Mina Ryten, Petr Vodicka, Alison J. Thomson, Tom Burdon, Henry Houlden, Fatima Cavaleri, Masumi Nagano, Nicola J. Drummond, Jan-Willem Taanman, Anthony H. Schapira, Katrina Gwinn, John Hardy, Patrick A. Lewis, Tilo Kunath. Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus. Nature Communications, 2011; 2: 440 DOI: 10.1038/ncomms1453

Cite This Page:

University of Edinburgh. "Stem cell study offers hope for Parkinson's patients." ScienceDaily. ScienceDaily, 23 August 2011. <www.sciencedaily.com/releases/2011/08/110823115157.htm>.
University of Edinburgh. (2011, August 23). Stem cell study offers hope for Parkinson's patients. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/08/110823115157.htm
University of Edinburgh. "Stem cell study offers hope for Parkinson's patients." ScienceDaily. www.sciencedaily.com/releases/2011/08/110823115157.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins