Featured Research

from universities, journals, and other organizations

New microscope might see beneath skin in 4-D

Date:
September 2, 2011
Source:
American Institute of Physics
Summary:
Other devices can take 3-D pictures of tissue below the surface of skin, but a new microscope adds an extra dimension: a spectroscopic "fingerprint" that measures the wavelength (or color) of light reflected off each point within a sample in a single snapshot. Researchers hope this innovation may one day be used for early detection of skin cancer.

A new type of laser scanning confocal microscope (LSCM) holds the promise of diagnosing skin cancer in a single snapshot.

Typical LSCMs take 3-D images of thick tissue samples by visualizing thin slices within that tissue one layer at a time. Sometimes scientists supplement these microscopes with spectrographs, which are devices that measure the pattern of wavelengths, or "colors," in the light reflected off of a piece of tissue. This pattern of wavelengths acts like a fingerprint, which scientists can use to identify a particular substance within the sample. But the range of wavelengths used so far with these devices has been narrow, limiting their uses.

Not so with the new microscope developed by physicists from the Consiglio Nazionale delle Ricerche (CNR) in Rome, and described in a paper accepted to the AIP's new journal AIP Advances. Unlike other combination "confocal microscope plus spectrograph" devices, the new machine is able to gather the spectrographic information from every point in a sample, at a wide range of wavelengths, and in a single scan.

To achieve this, the authors illuminate the sample with multiple colors of laser light at once -- a sort of "laser rainbow" -- that includes visible light as well as infrared. This allows scientists to gather a full range of information about the wavelengths of light reflected off of every point within the sample. Using this method, the researchers took high-resolution pictures of the edge of a silicon wafer and of metallic letters painted onto a piece of silicon less than half a millimeter wide.

They also demonstrated that it is possible to apply this technique to a tissue sample (in this case, chicken skin) without destroying it. With further testing, the researchers say the microscope could be used to detect early signs of melanoma; until then, it may be useful for non-medical applications, such as inspecting the surface of semiconductors.


Story Source:

The above story is based on materials provided by American Institute of Physics. Note: Materials may be edited for content and length.


Journal Reference:

  1. Stefano Selci, Francesca R. Bertani, Luisa Ferrari. Supercontinuum ultra wide range confocal microscope for reflectance spectroscopy of living matter and material science surfaces. AIP Advances, 2011; 1 (3): 032143 DOI: 10.1063/1.3631661

Cite This Page:

American Institute of Physics. "New microscope might see beneath skin in 4-D." ScienceDaily. ScienceDaily, 2 September 2011. <www.sciencedaily.com/releases/2011/08/110829114906.htm>.
American Institute of Physics. (2011, September 2). New microscope might see beneath skin in 4-D. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2011/08/110829114906.htm
American Institute of Physics. "New microscope might see beneath skin in 4-D." ScienceDaily. www.sciencedaily.com/releases/2011/08/110829114906.htm (accessed July 30, 2014).

Share This




More Matter & Energy News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Climate Change Could Cost Billions, According To White House

Climate Change Could Cost Billions, According To White House

Newsy (July 29, 2014) A report from the White House warns not curbing greenhouse gas emissions could cost the U.S. billions. Video provided by Newsy
Powered by NewsLook.com
Stranded Whale Watching Boat Returns to Boston

Stranded Whale Watching Boat Returns to Boston

Reuters - US Online Video (July 29, 2014) Passengers stuck overnight on a whale watching boat return safely to Boston. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Baluchistan Mining Eyes an Uncertain Future

Baluchistan Mining Eyes an Uncertain Future

AFP (July 29, 2014) Coal mining is one of the major industries in Baluchistan but a lack of infrastructure and frequent accidents mean that the area has yet to hit its potential. Duration: 01:58 Video provided by AFP
Powered by NewsLook.com
Easier Nuclear Construction Promises Fall Short

Easier Nuclear Construction Promises Fall Short

AP (July 29, 2014) The U.S. nuclear industry started building its first new plants using prefabricated Lego-like blocks meant to save time and prevent the cost overruns that crippled the sector decades ago. So far, it's not working. (July 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins