Featured Research

from universities, journals, and other organizations

Combination therapy rids common infection from implanted medical devices, researchers report

Date:
September 8, 2011
Source:
Public Library of Science
Summary:
Researchers have developed a therapy for a potentially deadly type of infection common in catheters, artificial joints and other 'in-dwelling' medical devices. The therapy targets fungal infections, which are hard to treat in such devices because they are composed of biofilms—complex groupings of cells that attach to surfaces. Biofilms, in turn, are coated in a gooey matrix that resists drugs.

Researchers at the University of Toronto have developed a therapy for a potentially deadly type of infection common in catheters, artificial joints and other "in-dwelling" medical devices. Their findings appear in the Open Access Journal PLoS Pathogens on September 8th.

Related Articles


The therapy targets fungal infections, which are hard to treat in such devices because they are composed of biofilms -- complex groupings of cells that attach to surfaces. Biofilms, in turn, are coated in a gooey matrix that resists drugs.

Patients often undergo surgical removal of the infected catheter or other device in an attempt to clear the disease and prevent a system-wide dispersal of infecting cells.

In this study, researchers showed that inhibiting the function of a protein called Hsp90 abolishes drug resistance in the two main fungal pathogens of humans, Candida albicans and Aspergillus fumigatus. "It takes classic antifungals, which were not effective against biofilms, and makes them very effective," said Prof. Leah Cowen, principal investigator on the study who holds the Canada Research Chair in Microbial Genomics and Infectious Disease at U of T's Department of Molecular Genetics.

In an animal model of a central venous catheter infected with deadly fungus, the researchers were able to completely clear the infection by inhibiting Hsp90 and applying antifungals.

Fungal pathogens are a major clinical problem. Candida albicans is the third-leading cause of intravascular catheter-related infections, and is fatal in about 30% of infections associated with devices. And the number of acquired fungal bloodstream infections has increased by more than 200% over the last two decades, partly because successful treatments for previously fatal diseases like cancer and AIDS have left many patients immune-compromised and susceptible to infection.

With more than 10 million patients per year now receiving catheters, artificial joints and other devices, there is a pressing need for a better understanding of biofilms and their role in drug resistance of fungal pathogens.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nicole Robbins, Priya Uppuluri, Jeniel Nett, Ranjith Rajendran, Gordon Ramage, Jose L. Lopez-Ribot, David Andes, Leah E. Cowen. Hsp90 Governs Dispersion and Drug Resistance of Fungal Biofilms. PLoS Pathogens, 2011; 7 (9): e1002257 DOI: 10.1371/journal.ppat.1002257

Cite This Page:

Public Library of Science. "Combination therapy rids common infection from implanted medical devices, researchers report." ScienceDaily. ScienceDaily, 8 September 2011. <www.sciencedaily.com/releases/2011/09/110908171628.htm>.
Public Library of Science. (2011, September 8). Combination therapy rids common infection from implanted medical devices, researchers report. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2011/09/110908171628.htm
Public Library of Science. "Combination therapy rids common infection from implanted medical devices, researchers report." ScienceDaily. www.sciencedaily.com/releases/2011/09/110908171628.htm (accessed October 30, 2014).

Share This



More Plants & Animals News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How A Chorus Led Scientists To A New Frog Species

How A Chorus Led Scientists To A New Frog Species

Newsy (Oct. 30, 2014) A frog noticed by a conservationist on New York's Staten Island has been confirmed as a new species after extensive study and genetic testing. Video provided by Newsy
Powered by NewsLook.com
Surfer Accidentally Stands on Shark, Gets Bitten

Surfer Accidentally Stands on Shark, Gets Bitten

AP (Oct. 30, 2014) A 20-year-old competition surfer said on Thursday he accidentally stepped on a shark's head before it bit him off the Australian east coast. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Ebola Inflicts Heavy Toll on Guinean Potato Trade

Ebola Inflicts Heavy Toll on Guinean Potato Trade

AFP (Oct. 30, 2014) The Ebola epidemic has seen Senegal and Guinea Bissau close its borders with Guinea and the economic consequences have started to be felt, especially in Fouta Djallon, where the renowned potato industry has been hit hard. Duration: 02:01 Video provided by AFP
Powered by NewsLook.com
Genetically Altered Glowing Flower on Display in Tokyo

Genetically Altered Glowing Flower on Display in Tokyo

Reuters - Innovations Video Online (Oct. 30, 2014) Just in time for Halloween, a glowing flower goes on display in Tokyo. Instead of sorcery and magic, its creators used science to genetically modify the flower, adding a naturally fluorescent plankton protein to its genetic mix. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins