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Study examines risk of aortic complications among patients with common congenital heart valve defect

Date:
September 14, 2011
Source:
JAMA and Archives Journals
Summary:
While the incidence of the life-threatening condition of aortic dissection is significantly higher than in the general population, it remains low among patients with the congenital heart defect, bicuspid aortic valve; however, the incidence of aortic aneurysms is significantly high, according to a new study.

While the incidence of the life-threatening condition of aortic dissection is significantly higher than in the general population, it remains low among patients with the congenital heart defect, bicuspid aortic valve; however, the incidence of aortic aneurysms is significantly high, according to a study in the September 14 issue of JAMA.

Bicuspid aortic valve (BAV; defect of the aortic valve that results in the formation of two flaps that open and close, instead of the normal three) is the most common congenital heart defect, with the most serious complication from this condition (due to the high risk of death) being aortic dissection (a tear involving the layers of the wall of the aorta). "… it is estimated that BAV is responsible for more deaths than all other congenital heart defects combined. Consequently, carriers live under the threat of sudden death," according to background information in the article. However, long-term, population-based data are lacking on the incidence of severe aortic complications among patients with BAV.

Hector I. Michelena, M.D., of the Mayo Clinic, Rochester, M inn., and colleagues conducted a study to determine the incidence of aortic complications among patients with BAV and in the general BAV population. The researchers analyzed long-term follow-up data of residents in Olmsted County, Minn., diagnosed with BAV by echocardiography from 1980 to 1999 and searched for aortic complications of patients whose bicuspid valves had gone undiagnosed. The last year of follow-up was 2008-2009. The study included 416 patients with BAV, with average follow-up of 16 years.

Over the study period, aortic dissection occurred in 2 of the 416 patients and the 25-year cohort risk of aortic dissection after echocardiographic diagnosis was 0.5 percent. In a comparison of incident rates, patients with BAV had a 8.4 times increased risk of aortic dissection compared with the county's general population, however, the absolute risk remained low. "The low aortic dissection incidence and lack of association with a detectable reduction in survival is reassuring," the authors write.

Of 384 patients without aortic aneurysms at the beginning of the study, 49 developed aneurysms at follow-up. The 25-year risk of aneurysm formation among BAV patients was 26 percent. Analysis of incidence rates indicated these patients had a 86 times higher risk of aneurysm formation compared with the general population. After aneurysm diagnosis, the 15-year risks of aortic surgery and aortic dissection were 46 percent and 7 percent, respectively. The 25-year risk of aortic surgery after BAV diagnosis was 25 percent.

The researchers also found that the dissection incidence was higher in patients older than 50 years and higher in those with baseline aortic aneurysms, "highlighting the importance of close monitoring and current guideline implementation in these subgroups."

Also, patients with BAV had a 25-year risk of valve replacement of 53 percent. "Our study confirms that aortic valve replacement remains the most common complication of patients with BAV. This highlights the importance of early recognition of BAV by careful cardiac auscultation [listening for sounds made by internal organs to aid in the diagnosis of certain disorders] in order to prevent heart failure due to late valvular surgery referrals, as well as potentially to prevent dissection by elective aorta surgical repair," the authors write.

"Research efforts should concentrate on elucidating biological pathways of BAV aortopathy [disease of the aorta] amenable to medical treatment, as well as identifying nonsize markers for refining risk prediction of aortic dissection in these patients," the researchers conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. H. I. Michelena, A. D. Khanna, D. Mahoney, E. Margaryan, Y. Topilsky, R. M. Suri, B. Eidem, W. D. Edwards, T. M. Sundt, M. Enriquez-Sarano. Incidence of Aortic Complications in Patients With Bicuspid Aortic Valves. JAMA: The Journal of the American Medical Association, 2011; 306 (10): 1104 DOI: 10.1001/jama.2011.1286

Cite This Page:

JAMA and Archives Journals. "Study examines risk of aortic complications among patients with common congenital heart valve defect." ScienceDaily. ScienceDaily, 14 September 2011. <www.sciencedaily.com/releases/2011/09/110913161941.htm>.
JAMA and Archives Journals. (2011, September 14). Study examines risk of aortic complications among patients with common congenital heart valve defect. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2011/09/110913161941.htm
JAMA and Archives Journals. "Study examines risk of aortic complications among patients with common congenital heart valve defect." ScienceDaily. www.sciencedaily.com/releases/2011/09/110913161941.htm (accessed April 17, 2014).

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