Featured Research

from universities, journals, and other organizations

Stents may reduce heart attacks by delivering downstream medication; Coating stents with medication may allow targeted delivery

Date:
September 15, 2011
Source:
Cleveland Clinic
Summary:
Researchers have discovered that cardiac patients receiving medicated stents -- a procedure that occurs often when blood vessels are blocked -- have a lower likelihood of suffering heart attacks or developing new blockages in the vessel downstream from the stent.

Researchers at Cleveland Clinic have discovered that cardiac patients receiving medicated stents -- a procedure that occurs often when blood vessels are blocked -- have a lower likelihood of suffering heart attacks or developing new blockages in the vessel downstream from the stent.

Stents have been used to prevent re-narrowing of coronary arteries after balloon angioplasty and newer designs have included coatings with medications to prevent re-narrowing from occurring within the stent after implantation. The recent study -- led by Richard Krasuski, M.D., Director of Adult Congenital Heart Disease Services and a staff cardiologist in the Section of Clinical Cardiology in the Department of Cardiovascular Medicine at the Miller Family Heart & Vascular Institute at Cleveland Clinic - suggests that these medicated stents may deliver the medication to the vessel beyond the stent.

In a study recently published in the American Heart Journal, Dr. Krasuski and his colleagues demonstrate that patients receiving medicated stents have a lower likelihood of suffering heart attacks or developing new blockages in the vessel downstream from the stent.

"Though there have been concerns about clots forming inside drug-releasing stents, the totality of data suggests that patients receiving drug-coated stents do better than patients receiving bare metal stents," Dr. Krasuski said. "It has not been clear before, however, why preventing re-blockage in the location of a stent would have such a large benefit, but our study suggests that there may be more that the stent is doing. When blood flows through the stent, medication not only reaches the vessel it is touching but likely the distal vessel as well. In this way it could be having a much more profound effect on the vessel."

If this concept is confirmed it could revolutionize treatment of cardiovascular disease and problems with other organ systems as well. Stents could be altered to deliver many different medications in small amounts directly to the blood vessels. This could maximize the benefits of different drugs and reduce their toxic effects as well as improve patient compliance.


Story Source:

The above story is based on materials provided by Cleveland Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. Richard A. Krasuski, George M. Cater, Ganesh P. Devendra, Kathy Wolski, Mehdi H. Shishehbor, Steven E. Nissen, Carlos Oberti, Stephen G. Ellis. Downstream coronary effects of drug-eluting stents. American Heart Journal, 2011; DOI: 10.1016/j.ahj.2011.08.001

Cite This Page:

Cleveland Clinic. "Stents may reduce heart attacks by delivering downstream medication; Coating stents with medication may allow targeted delivery." ScienceDaily. ScienceDaily, 15 September 2011. <www.sciencedaily.com/releases/2011/09/110915103610.htm>.
Cleveland Clinic. (2011, September 15). Stents may reduce heart attacks by delivering downstream medication; Coating stents with medication may allow targeted delivery. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2011/09/110915103610.htm
Cleveland Clinic. "Stents may reduce heart attacks by delivering downstream medication; Coating stents with medication may allow targeted delivery." ScienceDaily. www.sciencedaily.com/releases/2011/09/110915103610.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins