Featured Research

from universities, journals, and other organizations

Virus as a potential future cancer medicine?

Date:
September 19, 2011
Source:
University of Copenhagen
Summary:
Researchers have discovered that the vesicular stomatitis virus plays a previously unknown dual role in the prevention of a number of cancers.

In a new project, researchers from LIFE -- the Faculty of Life Sciences at the University of Copenhagen -- document that the vesicular stomatitis virus (VSV) plays a previously unknown dual role in the prevention of a number of cancers. The new findings show that the virus both kills cancer cells and stops the expression of the molecules which certain types of cancer cells produce to hide from the immune system.

Certain types of cancer cells express far too many liquid immunostimulatory molecules, blocking the immune system's ability to recognize them, and enabling them to continue the development of cancer.

"The overexpression seen in cancer types such as melanoma, testicular cancer, ovarian cancer and certain types of leukemia significantly impairs the immune system, thereby reducing the patient's chance of recovery," says associate professor in immunology S๘ren Skov from LIFE.

Skov is heading a research team which has just launched a major European project to study the potential for improving cancer treatment by strengthening the immune system.

Oncolytic virus

As part of the research project, PhD student Helle Jensen has infected human cancer cells with VSV.

"We were able to demonstrate that the virus kills cancer cells. The results also show that VSV effectively blocks the production of the immunostimulatory molecules which certain types of cancer overexpress to destroy the immune system and thus the chances of survival," Skov says.

Researchers believe the work is a major step towards better cancer treatment. The advance would enable the immune system to stop the development of cancer more effectively. In addition, it is possible to mutate the virus and adapt it to the relevant type of cancer. There is thus a potential for a future alternative to chemotherapy, tailored to the individual patient, says Skov.

"The next step will be clinical trials in humans. Such trials are already being conducted in the USA," says Jensen, who has carried out the research project at LIFE in collaboration with the Faculty of Health Sciences at the University of Copenhagen and the National Veterinary Institute at the Technical University of Denmark (DTU).


Story Source:

The above story is based on materials provided by University of Copenhagen. Note: Materials may be edited for content and length.


Cite This Page:

University of Copenhagen. "Virus as a potential future cancer medicine?." ScienceDaily. ScienceDaily, 19 September 2011. <www.sciencedaily.com/releases/2011/09/110916131304.htm>.
University of Copenhagen. (2011, September 19). Virus as a potential future cancer medicine?. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2011/09/110916131304.htm
University of Copenhagen. "Virus as a potential future cancer medicine?." ScienceDaily. www.sciencedaily.com/releases/2011/09/110916131304.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins