Featured Research

from universities, journals, and other organizations

Soy peptide plus chemo drug block colon cancer's spread to liver, study finds

Date:
September 19, 2011
Source:
University of Illinois College of Agricultural, Consumer and Environmental Sciences
Summary:
A new study reports a promising new weapon in treating metastatic colon cancer, particularly in patients who have developed resistance to chemotherapy. The research finds that the soy peptide lunasin binds to a specific receptor in highly metastatic colon cancer cells, preventing them from attaching to the liver.

A University of Illinois study reports a promising new weapon in treating metastatic colon cancer, particularly in patients who have developed resistance to chemotherapy.

U of I researcher Elvira de Mejia has found that the soy peptide lunasin binds to a specific receptor in highly metastatic colon cancer cells, preventing them from attaching to the liver.

"When lunasin was used in combination with the chemotherapy drug oxaliplatin, we saw a sixfold reduction in the number of new tumor sites," said de Mejia, a U of I associate professor of food chemistry and food toxicology.

The study appears in the most recent issue of Cancer Letters. In a separate study, the scientists showed that lunasin induces cell death in highly metastatic human colon cancer cells.

According to de Mejia, almost all colon cancer deaths are caused when cancer metastasizes -- or spreads -- to the liver. Until now chemotherapy has targeted the primary tumor because the process of metastasis is not well understood, she said.

"In this study, we have learned that lunasin can penetrate the cancer cell, cause cell death, and interact with at least one type of receptor in a cell that is ready to metastasize," said Vermont P. Dia, a U of I postdoctoral fellow in the de Mejia laboratory and lead author of the study.

When that receptor is blocked, new blood vessels can't form and differentiate, and that prevents cancer from spreading. Binding such receptors has emerged as a promising target for developing cancer therapies, he said.

In the study, which mimicked the spread of colon cancer in humans, mice were separated into four groups: a control group; a group that was injected daily with lunasin; a group injected with the chemo drug oxaliplatin; and a group that received both lunasin and oxaliplatin. After 28 days, the mice were examined to learn the extent of cancer's involvement in the liver.

"The group that received lunasin alone had 50 percent fewer metastatic sites. But an even more exciting result was seen in the group that received both lunasin and the chemotherapy drug -- only 5 new cancer sites when compared with 28 in the control group," de Mejia noted.

"This huge reduction in metastasis was achieved with the amount of lunasin in only 25 daily grams of soy protein, the amount recommended in the FDA health claim," Dia said.

The researchers said they recently analyzed commercial soy milks available in their area, and all contained lunasin. However, the amount of lunasin depended on the type of soy product that was used to prepare the soy milk.

"Two glasses of soy milk a day generally provide half the amount of lunasin used in our study," said de Mejia. "It certainly seems feasible to create a lunasin-enriched product that people could consume in a preventive way."

The scientists said their next step will be a colon cancer study in which they make lunasin part of the animals' diet -- rather than injecting the peptide -- to see if digestion and absorption alter its effectiveness. Soon they hope to be able to move on to human trials.

Dia received the American Oil Chemists Society's 2011 Hans Kaunitz Award for his work with lunasin.

Vermont P. Dia and Elvira de Mejia of the U of I are co-authors of both the study published in Cancer Letters and the in vitro study of lunasin's effect on human cancer cells published in Molecular Nutrition & Food Research. Funding was provided by the USDA, the U of I College of ACES Office of Research, and the Illinois Soybean Association.


Story Source:

The above story is based on materials provided by University of Illinois College of Agricultural, Consumer and Environmental Sciences. The original article was written by Phyllis Picklesimer. Note: Materials may be edited for content and length.


Journal References:

  1. Vermont P. Dia, Elvira Gonzalez de Mejia. Lunasin Potentiates the Effect of Oxaliplatin Preventing Outgrowth of Colon Cancer Metastasis, Binds to α5β1 Integrin and Suppresses FAK/ERK/NF-κB Signaling. Cancer Letters, 2011; DOI: 10.1016/j.canlet.2011.09.002
  2. Vermont P. Dia, Elvira Gonzalez de Mejia. Lunasin induces apoptosis and modifies the expression of genes associated with extracellular matrix and cell adhesion in human metastatic colon cancer cells. Molecular Nutrition & Food Research, 2011; 55 (4): 623 DOI: 10.1002/mnfr.201000419

Cite This Page:

University of Illinois College of Agricultural, Consumer and Environmental Sciences. "Soy peptide plus chemo drug block colon cancer's spread to liver, study finds." ScienceDaily. ScienceDaily, 19 September 2011. <www.sciencedaily.com/releases/2011/09/110919121841.htm>.
University of Illinois College of Agricultural, Consumer and Environmental Sciences. (2011, September 19). Soy peptide plus chemo drug block colon cancer's spread to liver, study finds. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2011/09/110919121841.htm
University of Illinois College of Agricultural, Consumer and Environmental Sciences. "Soy peptide plus chemo drug block colon cancer's spread to liver, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/09/110919121841.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins