Featured Research

from universities, journals, and other organizations

Knockout of protein prevents colon tumor formation in mice

Date:
September 30, 2011
Source:
University of Illinois at Chicago
Summary:
A protein that regulates differentiation in normal tissue may play a very different role in colon and breast cancer, activating proliferation of damaged cells, according to researchers.

A protein that regulates cell differentiation in normal tissue may play a different role in colon and breast cancer, activating proliferation of damaged cells, according to researchers at the University of Illinois at Chicago College of Medicine.

Related Articles


The protein, called PTK6, is found in normal skin and gut cells -- and in cancerous, but not normal, breast tissue.

"Our research has primarily focused on the normal function of this protein in the gut, where it regulates growth and differentiation," said Angela Tyner, professor of biochemistry and molecular genetics.

Epithelial cells, such as skin cells and the cells that line the colon, turn over rapidly. To replace them, new cells must be continuously produced that become specialized, or differentiated, to perform specific functions.

To further their investigation of PTK6, Tyner and her colleagues developed a mouse that lacked the PTK6 gene. Based on their observation of increased growth in the intestine, Tyner's group suspected that mice lacking PTK6 would be more susceptible to cancer.

Using a carcinogen, the researchers induced colon tumors resembling human sporadic colon cancer in mice lacking the PTK6 gene and in normal mice.

"Mice lacking PTK6 were highly resistant to the carcinogen and developed fewer tumors," Tyner said. "It was an unexpected result."

Tyner and her colleagues were able to establish the reason for this unexpected result. They found that PTK6 was activating a protein responsible for turning genes on and off called STAT3. Previous studies have established a role for STAT3 in proliferation and found that it plays an important role in many epithelial cancers, including skin cancer and colon cancer.

PTK6 seems to be playing opposite roles in normal and cancer cells, Tyner said.

"We believe that PTK6 may play a role in initiation of cancer in the colon, but we don't yet know what role PTK6 may play in metastasis."

Tyner's laboratory is continuing to investigate the role of PTK6 in cancer, which may provide a future target for therapies not only for colon cancer but breast cancer as well.

The study, published in Gastroenterology, was supported by the National Institutes of Health and the American Gastroenterological Association. Jessica Gierut was the study's first author, and Yu Zheng, Wenjun Bie, Robert Carroll, Susan Ball-Kell and Andrea Haegebarth also contributed to the study.


Story Source:

The above story is based on materials provided by University of Illinois at Chicago. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jessica Gierut, Yu Zheng, Wenjun Bie, Robert E. Carroll, Susan Ball-Kell, Andrea Haegebarth, Angela L. Tyner. Disruption of the Mouse Protein Tyrosine Kinase 6 Gene Prevents STAT3 Activation and Confers Resistance to Azoxymethane. Gastroenterology, 2011; DOI: 10.1053/j.gastro.2011.06.071

Cite This Page:

University of Illinois at Chicago. "Knockout of protein prevents colon tumor formation in mice." ScienceDaily. ScienceDaily, 30 September 2011. <www.sciencedaily.com/releases/2011/09/110929161341.htm>.
University of Illinois at Chicago. (2011, September 30). Knockout of protein prevents colon tumor formation in mice. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2011/09/110929161341.htm
University of Illinois at Chicago. "Knockout of protein prevents colon tumor formation in mice." ScienceDaily. www.sciencedaily.com/releases/2011/09/110929161341.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins