Featured Research

from universities, journals, and other organizations

Knockout of protein prevents colon tumor formation in mice

Date:
September 30, 2011
Source:
University of Illinois at Chicago
Summary:
A protein that regulates differentiation in normal tissue may play a very different role in colon and breast cancer, activating proliferation of damaged cells, according to researchers.

A protein that regulates cell differentiation in normal tissue may play a different role in colon and breast cancer, activating proliferation of damaged cells, according to researchers at the University of Illinois at Chicago College of Medicine.

The protein, called PTK6, is found in normal skin and gut cells -- and in cancerous, but not normal, breast tissue.

"Our research has primarily focused on the normal function of this protein in the gut, where it regulates growth and differentiation," said Angela Tyner, professor of biochemistry and molecular genetics.

Epithelial cells, such as skin cells and the cells that line the colon, turn over rapidly. To replace them, new cells must be continuously produced that become specialized, or differentiated, to perform specific functions.

To further their investigation of PTK6, Tyner and her colleagues developed a mouse that lacked the PTK6 gene. Based on their observation of increased growth in the intestine, Tyner's group suspected that mice lacking PTK6 would be more susceptible to cancer.

Using a carcinogen, the researchers induced colon tumors resembling human sporadic colon cancer in mice lacking the PTK6 gene and in normal mice.

"Mice lacking PTK6 were highly resistant to the carcinogen and developed fewer tumors," Tyner said. "It was an unexpected result."

Tyner and her colleagues were able to establish the reason for this unexpected result. They found that PTK6 was activating a protein responsible for turning genes on and off called STAT3. Previous studies have established a role for STAT3 in proliferation and found that it plays an important role in many epithelial cancers, including skin cancer and colon cancer.

PTK6 seems to be playing opposite roles in normal and cancer cells, Tyner said.

"We believe that PTK6 may play a role in initiation of cancer in the colon, but we don't yet know what role PTK6 may play in metastasis."

Tyner's laboratory is continuing to investigate the role of PTK6 in cancer, which may provide a future target for therapies not only for colon cancer but breast cancer as well.

The study, published in Gastroenterology, was supported by the National Institutes of Health and the American Gastroenterological Association. Jessica Gierut was the study's first author, and Yu Zheng, Wenjun Bie, Robert Carroll, Susan Ball-Kell and Andrea Haegebarth also contributed to the study.


Story Source:

The above story is based on materials provided by University of Illinois at Chicago. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jessica Gierut, Yu Zheng, Wenjun Bie, Robert E. Carroll, Susan Ball-Kell, Andrea Haegebarth, Angela L. Tyner. Disruption of the Mouse Protein Tyrosine Kinase 6 Gene Prevents STAT3 Activation and Confers Resistance to Azoxymethane. Gastroenterology, 2011; DOI: 10.1053/j.gastro.2011.06.071

Cite This Page:

University of Illinois at Chicago. "Knockout of protein prevents colon tumor formation in mice." ScienceDaily. ScienceDaily, 30 September 2011. <www.sciencedaily.com/releases/2011/09/110929161341.htm>.
University of Illinois at Chicago. (2011, September 30). Knockout of protein prevents colon tumor formation in mice. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2011/09/110929161341.htm
University of Illinois at Chicago. "Knockout of protein prevents colon tumor formation in mice." ScienceDaily. www.sciencedaily.com/releases/2011/09/110929161341.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins