Featured Research

from universities, journals, and other organizations

Race to nerve regeneration: Faster is better

Date:
October 3, 2011
Source:
Journal of Clinical Investigation
Summary:
Researchers have now identified a way to accelerate the regeneration of injured peripheral nerves in mice such that muscle function is restored in situations where it normally would not be. It is hoped that these data might one day translate into strategies that increase the rate of nerve growth to enhance functional recovery in patients after peripheral nerve damage.

A team of researchers led by Clifford Woolf and Chi Ma, at Children's Hospital Boston and Harvard Medical School, Boston, has identified a way to accelerate the regeneration of injured peripheral nerves in mice such that muscle function is restored.

In an accompanying commentary, Ahmet H๖ke, at Johns Hopkins School of Medicine, Baltimore, discusses the importance of this work to the clinical problem.

Our peripheral nerves connect our brain and spinal cord to the rest of our body, controlling all volitional muscle movements. However, they are fragile and very easily damaged. Peripheral nerves can regenerate after injury, and if the site of damage is close to the muscle controlled by the damaged nerve, full muscle function is frequently restored. However, if the site of damage is far from the muscle controlled by the damaged nerve, recovery of muscle function is minimal.

Woolf, Ma, and colleagues found that injured peripheral nerves grew faster in mice that overexpressed human heat shock protein 27 (Hsp27) than in normal mice. This enabled the peripheral nerves to form functional connections with their target muscle and led to recovery of muscle function. Clinical data are also provided to support the authors' suggestion that their work indicates that strategies that increase the rate of nerve growth may enhance functional recovery in patients after peripheral nerve damage.

The research is reported in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. Chi Him Eddie Ma, Takao Omura, Enrique J. Cobos, Alban Latr้moli่re, Nader Ghasemlou, Gary J. Brenner, Ed van Veen, Lee Barrett, Tomokazu Sawada, Fuying Gao, Giovanni Coppola, Frank Gertler, Michael Costigan, Dan Geschwind, Clifford J. Woolf. Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI58675
  2. Ahmet H๖ke. A (heat) shock to the system promotes peripheral nerve regeneration. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI59320

Cite This Page:

Journal of Clinical Investigation. "Race to nerve regeneration: Faster is better." ScienceDaily. ScienceDaily, 3 October 2011. <www.sciencedaily.com/releases/2011/10/111003131417.htm>.
Journal of Clinical Investigation. (2011, October 3). Race to nerve regeneration: Faster is better. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2011/10/111003131417.htm
Journal of Clinical Investigation. "Race to nerve regeneration: Faster is better." ScienceDaily. www.sciencedaily.com/releases/2011/10/111003131417.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) — America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) — China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

More Coverage


In Reversing Motor Nerve Damage, Time Is of the Essence: 'Wait and See' In Injuries Like Carpal Tunnel Syndrome May Miss a Window for Recovery

Oct. 3, 2011 — When a motor nerve is severely damaged, people rarely recover full muscle strength and function. Combining patient data with observations in a mouse model, neuroscientists now show why. It's not ... read more
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins