Featured Research

from universities, journals, and other organizations

Researchers discover new enzyme function for anemia

Date:
October 3, 2011
Source:
St. Michael's Hospital
Summary:
Researchers have discovered a new function for an enzyme that may protect against organ injury and death from anemia.

Researchers at St. Michael's Hospital have discovered a new function for an enzyme that may protect against organ injury and death from anemia.

Related Articles


"Identifying this mechanism may lead to new therapies and approaches to improving outcomes for anemic patients," said Dr. Greg Hare, a researcher at the Li Ka Shing Knowledge Institute of the hospital and one of the lead investigators of the study.

One in four people around the world and up to 50 per cent of patients coming for surgery are anemic. The condition has many different causes including infection (malaria, HIV, parasites), nutritional deficiencies (iron, folate, B12), genetic mutations, pregnancy, trauma and surgical blood loss.

Anemia occurs when blood has a lower than normal number of red blood cells or hemoglobin -- an iron-rich protein that carries oxygen from the lungs and heart to the rest of the body. Cells need oxygen to survive and to produce energy for all bodily functions.

Dr. Hare and colleagues found that when people have anemia, neuronal nitric oxide synthase (nNOS) -- an enzyme in nerve cells that produces nitric oxide, an important signaling molecule in the body -- increases the body's ability to respond, adapt to low oxygen levels and makes the body more efficient in delivering oxygen to tissues.

The researchers found levels of nNOS in the brain increased in anemic mice, and that the mice without this enzyme die earlier, and with higher hemoglobin levels.

The research appeared the October 3 issue of Proceeding of the National Academy of Sciences.

"This research will help us identify when an anemic patient is at greatest risk for injury and death when undergoing surgery," said Dr. Hare. "Research is underway to test these findings in humans."


Story Source:

The above story is based on materials provided by St. Michael's Hospital. Note: Materials may be edited for content and length.


Cite This Page:

St. Michael's Hospital. "Researchers discover new enzyme function for anemia." ScienceDaily. ScienceDaily, 3 October 2011. <www.sciencedaily.com/releases/2011/10/111003151832.htm>.
St. Michael's Hospital. (2011, October 3). Researchers discover new enzyme function for anemia. ScienceDaily. Retrieved December 17, 2014 from www.sciencedaily.com/releases/2011/10/111003151832.htm
St. Michael's Hospital. "Researchers discover new enzyme function for anemia." ScienceDaily. www.sciencedaily.com/releases/2011/10/111003151832.htm (accessed December 17, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, December 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com
Feeling Young Might Mean A Longer Life Span

Feeling Young Might Mean A Longer Life Span

Newsy (Dec. 16, 2014) A study published in JAMA shows that people who feel younger than their chronological age might actually live longer than those who feel old. Video provided by Newsy
Powered by NewsLook.com
2016 Olympic Waters Feature 'Super Bacteria' Researchers Say

2016 Olympic Waters Feature 'Super Bacteria' Researchers Say

Newsy (Dec. 16, 2014) Researchers found the bacteria Klebsiella pneumoniae Carbapenemase in the water where the 2016 Olympics is supposed to take place. Video provided by Newsy
Powered by NewsLook.com
'Super Bacteria' Found in Rio's Olympic Waters

'Super Bacteria' Found in Rio's Olympic Waters

AP (Dec. 16, 2014) Scientists with Brazil's most respected health research institute say they've discovered a drug-resistant "super bacteria" in waters where Olympic sailing events will be held. (Dec. 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins