Featured Research

from universities, journals, and other organizations

Newly identified gene may be risk factor for osteoporosis

Date:
October 5, 2011
Source:
Institut de recherches cliniques de Montreal
Summary:
Researchers have identified a new gene that modulates bone mass and that could become a risk factor for developing osteoporosis.

Researchers at the Institut de recherches cliniques de Montréal (IRCM), directed by Dr. Jean Vacher, identified a new gene that modulates bone mass and that could become a risk factor for developing osteoporosis. This scientific breakthrough will be published October 4 in the scientific journal Cell Metabolism.

Osteoporosis is a "silent" genetic disease characterized by low bone mineral density and deterioration of bone tissue, which leads to increased bone fragility and risk of fracture. In all cases, the disease is caused by an imbalance between the formation and resorption of bone tissue.

"The overall objective of our research is to understand the molecular and cellular mechanisms that determine the balance between bone formation and resorption (breakdown)," explains Dr. Vacher, Director of the Cellular Interactions and Development research unit at the IRCM. "Osteoblasts are responsible for making bones and work in synergy with osteoclasts, which reshape the bone. To gain insight into these complex mechanisms, we are studying the role of new genes that influence osteoclasts and osteoblasts."

The team of researchers recently isolated a gene that modulates osteoclasts. They found, in mice, that a loss of this gene's function leads to a significant increase in the number of osteoclasts, thereby generating an even higher level of bone resorption.

"We identified this gene as a novel modulator of bone mineral density in mice and humans," adds Dr. Vacher. "More importantly, we showed that the human gene could represent a new susceptibility factor for osteoporosis. Hence, this discovery will help identify individuals with a greater predisposition to the disease who could benefit from preventive measures."

According to Osteoporosis Canada, as many as two million Canadians suffer from osteoporosis. One in four women over the age of 50 has osteoporosis, and so does one in eight men over the same age. In addition, 80 per cent of hip fractures are related to the disease. These result in death in up to 20 per cent of cases, and disability in 50 per cent of those who survive.

Mathieu Ferron, graduate student from Dr. Vacher's laboratory, is the article's first author. This research project was conducted in collaboration with scientists at Université Laval in Québec and Washington University School of Medicine in Saint Louis.

Research carried out at the IRCM was funded by the Canadian Institutes of Health Research (CIHR) and the Natural Sciences and Engineering Research Council of Canada (NSERC).


Story Source:

The above story is based on materials provided by Institut de recherches cliniques de Montreal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mathieu Ferron, Maya Boudiffa, Michel Arsenault, Mohamed Rached, Monica Pata, Sylvie Giroux, Latifa Elfassihi, Marina Kisseleva, Philip W. Majerus, François Rousseau et al. Inositol Polyphosphate 4-Phosphatase B as a Regulator of Bone Mass in Mice and Humans. Cell Metabolism, 14(4) pp. 466 - 477; 5 October 2011 DOI: 10.1016/j.cmet.2011.08.013

Cite This Page:

Institut de recherches cliniques de Montreal. "Newly identified gene may be risk factor for osteoporosis." ScienceDaily. ScienceDaily, 5 October 2011. <www.sciencedaily.com/releases/2011/10/111004132534.htm>.
Institut de recherches cliniques de Montreal. (2011, October 5). Newly identified gene may be risk factor for osteoporosis. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2011/10/111004132534.htm
Institut de recherches cliniques de Montreal. "Newly identified gene may be risk factor for osteoporosis." ScienceDaily. www.sciencedaily.com/releases/2011/10/111004132534.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) — President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) — A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) — A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) — A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins