Featured Research

from universities, journals, and other organizations

Activating brown fat: Research finding may lead to new treatments for obesity and Type 2 diabetes

Date:
October 29, 2011
Source:
University of Cincinnati Academic Health Center
Summary:
Activating a specialized type of fat, known as brown adipose tissue, may help combat obesity as well as result in better glucose control for Type 2 diabetes, according to new research.

Activating a specialized type of fat, known as brown adipose tissue, may help combat obesity as well as result in better glucose control for type 2 diabetes, according to new research conducted by scientists at the UC Metabolic Diseases Institute.

Related Articles


The current UC study suggests that activating brown adipose tissue through targeted inhibition of the cannabinoid receptor 1, also known as CB1, could effectively reduce body weight and blood glucose by increasing calorie burning in brown adipose tissue.

Silvana Obici, MD, and her UC-based team report these findings online ahead of print Oct. 10, 2011, in Diabetologia, the journal of the European Association for the Study of Diabetes.

CB1 receptor antagonists were previously used in human weight loss drugs offered in Europe but were taken off the market due to significant neurologic side effects like depression.

"CB1 antagonists still hold promise for fighting obesity and diabetes -- the challenge is finding one that does not engage the receptors in areas of the brain that control mood and still maintains its enormous calorie-burning properties," explains Obici, senior author of the UC study. "We have shown that the powerful effects of CB1 antagonists on brown adipose tissue are mediated by the sympathetic nervous system. With further study, this could lead to a more effective and safer drug strategy for glucose regulation and weight loss."

Obici is now conducting further studies to determine the specific location of the CB1 receptor in the sympathetic nervous system that activates the calorie-burning, glucose-consuming properties of brown adipose tissue.

"Our findings suggest that the capacity of brown adipose tissue to burn calories and consume glucose is impaired in obesity and type 2 diabetes. If we could find an effective and safe way to reactivate the brown adipose tissue's calorie-burning properties, this could represent a breakthrough in the search of more effective drugs against obesity and diabetes,," Obici adds.

Funding support for this research comes from the National Institutes of Health, American Diabetes Association and Ethicon Endo-Surgery. Researchers involved in this study have no personal financial interests in Ethicon Endo-Surgery.


Story Source:

The above story is based on materials provided by University of Cincinnati Academic Health Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Bajzer, M. Olivieri, M. K. Haas, P. T. Pfluger, I. J. Magrisso, M. T. Foster, M. H. Tschφp, K. A. Krawczewski-Carhuatanta, D. Cota, S. Obici. Cannabinoid receptor 1 (CB1) antagonism enhances glucose utilisation and activates brown adipose tissue in diet-induced obese mice. Diabetologia, 2011; DOI: 10.1007/s00125-011-2302-6

Cite This Page:

University of Cincinnati Academic Health Center. "Activating brown fat: Research finding may lead to new treatments for obesity and Type 2 diabetes." ScienceDaily. ScienceDaily, 29 October 2011. <www.sciencedaily.com/releases/2011/10/111011112807.htm>.
University of Cincinnati Academic Health Center. (2011, October 29). Activating brown fat: Research finding may lead to new treatments for obesity and Type 2 diabetes. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2011/10/111011112807.htm
University of Cincinnati Academic Health Center. "Activating brown fat: Research finding may lead to new treatments for obesity and Type 2 diabetes." ScienceDaily. www.sciencedaily.com/releases/2011/10/111011112807.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins