Featured Research

from universities, journals, and other organizations

Stem cells, signaling pathways identified in lung repair

Date:
October 12, 2011
Source:
National Jewish Health
Summary:
Researchers have identified cells and signaling molecules that trigger the repair of injured lungs. The scientists report that destruction of lung tissue in mice induces smooth muscle cells surrounding the airways to secrete a protein known as fibroblast growth factor 10, which induces surviving epithelial cells in the airways to revert to a stem-cell state, proliferate, repair and repopulate the lining of the lungs.

Researchers at National Jewish Health have identified cells and signaling molecules that trigger the repair of injured lungs. Stijn De Langhe, PhD, and his colleagues report October 10, 2011, online in the Journal of Clinical Investigation, that destruction of lung tissue in mice induces smooth muscle cells surrounding the airways to secrete a protein known as fibroblast growth factor 10 (FGF10), which induces surviving epithelial cells in the airways to revert to a stem-cell state, proliferate, repair and repopulate the lining of the lungs.

"The repair process in the lungs turns out to be very similar to the developmental process that originally formed the lungs," said Dr. De Langhe, Assistant Professor of Pediatrics at National Jewish Health. "These findings identify important cells and signaling molecules that could be used in therapeutic strategies to promote repair of injured lungs and turn off aberrant repair that occurs in many lung diseases."

In mouse lungs, most cells lining the airways were destroyed as a result of exposure to toxic substances napthalene, ozone or bleomycin. One type, known as variant Clara cells, however, resisted damage from those substances.

In a series of experiments, Dr. De Langhe and his colleagues showed that nearby parabronchial smooth muscle cells began secreting FGF10 soon after the injury. The FGF caused the variant Clara cells to revert to their original stem-cell state. They proliferated and restored the full complement of epithelial cells lining the airways, thus repairing the injury.

These findings could be valuable for both turning on and off the repair process. In acute lung injury, it could be valuable to augment the repair process. But in other diseases, such as asthma and pulmonary fibrosis, the repair process goes awry leading to scarring or build up of excess cells in the airways. Turning off the repair process might help treat those diseases.


Story Source:

The above story is based on materials provided by National Jewish Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Thomas Volckaert, Erik Dill, Alice Campbell, Caterina Tiozzo, Susan Majka, Saverio Bellusci, Stijn P. De Langhe. Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI58097

Cite This Page:

National Jewish Health. "Stem cells, signaling pathways identified in lung repair." ScienceDaily. ScienceDaily, 12 October 2011. <www.sciencedaily.com/releases/2011/10/111011121418.htm>.
National Jewish Health. (2011, October 12). Stem cells, signaling pathways identified in lung repair. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2011/10/111011121418.htm
National Jewish Health. "Stem cells, signaling pathways identified in lung repair." ScienceDaily. www.sciencedaily.com/releases/2011/10/111011121418.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins