Featured Research

from universities, journals, and other organizations

Certain mouth bacteria signal pancreatic cancer, study finds

Date:
October 13, 2011
Source:
BMJ-British Medical Journal
Summary:
Particular types of mouth bacteria, some of which are found in gum disease, are associated with the development of pancreatic cancer, indicates a small study.

Particular types of mouth bacteria, some of which are found in gum disease, are associated with the development of pancreatic cancer, indicates a small study published online in the journal Gut.

Related Articles


The finding opens up the possibility of curbing the progress of one of the most difficult cancers to treat, by altering the balance of bacteria, say the authors. Pancreatic cancer usually spreads very quickly, and only around one in 20 patients is still alive five years after diagnosis.

The authors base their findings on an initial comparison of the bacteria found in the spit of 10 patients with pancreatic cancer, which had not yet spread, and 10 healthy people, matched for age and sex.

They found significant differences between the bacterial colonies in the two groups, with 31 additional species and 25 fewer species in the spit of the cancer patients.

They then checked spit samples from a further 28 pancreatic cancer patients and 28 healthy people to verify their findings.

And they checked tissue samples from 28 patients with chronic inflammation of the pancreas (chronic pancreatitis), which is associated with an increased risk of developing pancreatic cancer. Among six suspicious species, two -- Neisseria elongata and Streptococcus mitis -- showed up significantly less often in the mouths of the cancer patients than in those of their healthy peers, while levels of another species -- Granulicatella adjacens -- were significantly higher.

The combination of N Elongata and S mitis accurately differentiated between healthy patients and those with cancer in more than 80% cases.

Furthermore, they found similar differences in the prevalence of S mitis and G adjacens between the chronic pancreatitis samples and the spit of healthy people.

It is as yet unclear whether the presence of particular types of bacteria are a cause or effect of pancreatic cancer, say the authors. But their findings back previous research, which has implicated bacteria in the development of pancreatic diseases.

They go on to suggest that levels of certain bacteria could be used as a non-invasive and credible screen for pancreatic cancer, with the promise of earlier detection for a disease that has no clear symptoms in its early stages.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. James J Farrell, Lei Zhang, Hui Zhou, David Chia, David Elashoff, David Akin, Bruce J Paster, Kaumudi Joshipura, David TW Wong. Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer. Gut, 2011; DOI: 10.1136/gutjnl-2011-300784

Cite This Page:

BMJ-British Medical Journal. "Certain mouth bacteria signal pancreatic cancer, study finds." ScienceDaily. ScienceDaily, 13 October 2011. <www.sciencedaily.com/releases/2011/10/111012185639.htm>.
BMJ-British Medical Journal. (2011, October 13). Certain mouth bacteria signal pancreatic cancer, study finds. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2011/10/111012185639.htm
BMJ-British Medical Journal. "Certain mouth bacteria signal pancreatic cancer, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/10/111012185639.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins