Featured Research

from universities, journals, and other organizations

Sterilization method for dialyzer membrane used for hemodialysis associated with increased risk of developing low platelet counts

Date:
October 20, 2011
Source:
JAMA and Archives Journals
Summary:
Patients who had undergone hemodialysis using dialyzers that had been sterilized with the use of electron beams were more likely to develop thrombocytopenia (an abnormally low platelet count in the blood, associated with increased risk of bleeding), according to a new study.

Patients who had undergone hemodialysis using dialyzers that had been sterilized with the use of electron beams were more likely to develop thrombocytopenia (an abnormally low platelet count in the blood, associated with increased risk of bleeding), according to a study in the October 19 issue of JAMA.

"Adverse device reactions to hemodialysis treatments are uncommon but can still occur in today's era of hemodialysis membranes and technology. During hemodialysis treatment, patients are exposed to a variety of components of the dialysis circuit and could have an adverse reaction to blood tubing, dialyzer membranes [used in the dialysis machines], and dialysis solutions," according to background information in the article. "Thrombocytopenia is not widely recognized as a potential dialyzer-related complication. Following the observation of significant thrombocytopenia among 20 patients undergoing hemodialysis in a single dialysis unit after the introduction of dialyzers sterilized by electron beam (e-beam), a larger investigation was undertaken."

Mercedeh Kiaii, M.D., F.R.C.P.C., of the University of British Columbia, Vancouver, Canada, and colleagues conducted a study to determine the prevalence and cause of thrombocytopenia in patients undergoing hemodialysis in British Columbia and southern Alberta province between April 2009 and November 2010. Retrospective analyses of historical patient, laboratory, and dialyzer data predating conversion to e-beam dialyzers were undertaken, with prospective collection of predialysis and postdialysis platelet counts before and after the change from e-beam to non-e-beam sterilized dialyzers in September 2009. Significant thrombocytopenia was defined as post-dialysis treatment platelet count of less than 100 x 103/μL and a postdialysis decrease in platelet count of more than 15 percent.

Province-wide testing of all patients from British Columbia who underwent hemodialysis in community and hospital-based facilities permitted collection of data from the majority (80 percent) of patients with hemodialysis from British Columbia (1,706 of 2,146 patients) and from Alberta (425 patients). Of the 1,706 patients from British Columbia, 1,411 patients (83 percent) were undergoing dialysis using e-beam sterilized membranes. In British Columbia, 11.4 percent of patients (n = 194) had postdialysis platelet counts of less than 100 x 103/μL, 23.4 percent of patients (n = 400) had more than 15 percent decrease in platelet count postdialysis, and 7.2 percent of patients (n= 123) met both criteria. Similar proportions from the Alberta population who were undergoing dialysis using a polysulfone e-beam sterilized dialyzer made by a different manufacturer were demonstrated (10.8 percent; n=46 had postdialysis platelet counts of less than 100 x 103/μL; 32.0 percent; n= 156 had more than 15 percent decrease in platelet count postdialysis; and 7.3 percent (n = 31) met both criteria.

In multivariate analysis adjusting for patient and dialysis history characteristics, use of an e-beam sterilized dialyzer was associated with a 2.5 times increased risk of significant thrombocytopenia. "Overall, among 1,784 patients, there were significant reductions in postdialysis thrombocytopenia following the change to use of non-e-beam sterilized dialyzers, such that 120 patients (6.7 percent) had platelet counts of less than 100 x 103/μL; 167 patients (9.4 percent) had decreases in platelet counts of greater than 15 percent; and 38 patients (2.1 percent) met both criteria," the authors write.

"Our study highlights 2 important points in the care of patients undergoing hemodialysis. First, dialyzer reactions such as thrombocytopenia can occur even with the use of current technologically advanced dialyzer membranes and devices. Second, these reactions may be overlooked with current routine predialysis blood work. Hemodialysis unit protocols and guidelines might consider adding postdialysis blood counts to routinely performed blood work when new dialyzers are introduced to help identify possible dialyzer-associated adverse effects," the authors write.

The researchers add that it is biologically plausible that e-beam sterilization could induce changes in platelets by a number of possible mechanisms, but none of these have been thoroughly evaluated.

Editorial: Optimizing Patient Safety During Hemodialysis

In an accompanying editorial, Jonathan Himmelfarb, M.D., of the University of Washington, Seattle, comments on the findings of this study.

"This systematic, multifaceted study clearly demonstrated a robust association of thrombocytopenia risk with use of e-beam sterilization of dialyzers. It is also an exemplary model for investigating other problems that can affect patient safety during complex procedures such as dialysis. Several recently published single-patient case reports also have implicated e-beam sterilization as a possible cause of dialysis-induced thrombocytopenia."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal References:

  1. M. Kiaii, O. Djurdjev, M. Farah, A. Levin, B. Jung, J. MacRae. Use of Electron-Beam Sterilized Hemodialysis Membranes and Risk of Thrombocytopenia. JAMA: The Journal of the American Medical Association, 2011; 306 (15): 1679 DOI: 10.1001/jama.2011.1499
  2. J. Himmelfarb. Optimizing Patient Safety During Hemodialysis. JAMA: The Journal of the American Medical Association, 2011; 306 (15): 1707 DOI: 10.1001/jama.2011.1507

Cite This Page:

JAMA and Archives Journals. "Sterilization method for dialyzer membrane used for hemodialysis associated with increased risk of developing low platelet counts." ScienceDaily. ScienceDaily, 20 October 2011. <www.sciencedaily.com/releases/2011/10/111020025642.htm>.
JAMA and Archives Journals. (2011, October 20). Sterilization method for dialyzer membrane used for hemodialysis associated with increased risk of developing low platelet counts. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2011/10/111020025642.htm
JAMA and Archives Journals. "Sterilization method for dialyzer membrane used for hemodialysis associated with increased risk of developing low platelet counts." ScienceDaily. www.sciencedaily.com/releases/2011/10/111020025642.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins