Featured Research

from universities, journals, and other organizations

Exenatide (Byetta) has rapid, powerful anti-inflammatory effect, study shows

Date:
November 3, 2011
Source:
University at Buffalo
Summary:
Exenatide, a drug commonly prescribed to help patients with Type 2 diabetes improve blood sugar control, also has a powerful and rapid anti-inflammatory effect, a new study has shown.

Exenatide, a drug commonly prescribed to help patients with type 2 diabetes improve blood sugar control, also has a powerful and rapid anti-inflammatory effect, a University at Buffalo study has shown.

Related Articles


The study of the drug, marketed under the trade name Byetta, was published recently in the Journal of Clinical Endocrinology and Metabolism.

"Our most important finding was this rapid, anti-inflammatory effect, which may lead to the inhibition of atherosclerosis, the major cause of heart attacks, strokes and gangrene in diabetics," says Paresh Dandona, MD, UB Distinguished Professor in the Department of Medicine, UB School of Medicine and Biomedical Sciences, and senior author.

It was especially noteworthy that this anti-inflammatory effect occurred independently of weight loss over the 12-week study period, he adds.

"The fact that the drug caused this dramatic and comprehensive anti-inflammatory effect independent of weight loss shows that it is a primary action of the drug and is not dependent upon weight loss," says Ajay Chaudhuri, MD, associate professor of medicine at UB and lead author.

He explains that, since obesity is an inflammatory state and adipose tissue contributes to inflammation, weight loss on its own can lead to an anti-inflammatory effect.

"Even more importantly, a short-lived anti-inflammatory effect was observed within two hours following a single injection of 5 micrograms of the drug," Chaudhuri continues. "This coincides with the peak concentration of the drug after the injection. Such a rapid and dramatic effect is rare."

"Apart from corticosteroids, which are known anti-inflammatory drugs, and insulin, no other drug demonstrates such a powerful and rapid anti-inflammatory effect," adds Dandona.

As a result, he and his colleagues at UB plan to study how exenatide might be used in acute inflammatory settings in the intensive care unit or following heart attacks and strokes, where a rapid anti-inflammatory effect is required and such drugs may be of potential use.

In addition to the anti-inflammatory effect, participants also exhibited a drop in the measurement of average blood sugar levels over three months, called hemoglobin A1C, from 8.6 percent to 7.4 percent.

The study involved 24 obese type 2 diabetics who were already on insulin to control their glucose levels.

The current study was undertaken based on previous observations published in 2007 by the UB researchers that exenatide indicated an anti-inflammatory effect, reducing plasma C-reactive protein levels, triglycerides and systolic blood pressure.

Co-authors with Chaudhuri and Dandona are Mehul Vora, MD, clinical assistant instructor of medicine; Husam Ghanim, PhD, research assistant professor of medicine; Sandeep Dhindsa, MD, and Antoine Makdissi, MD, both assistant professors of medicine; and Chang Ling Sia and Kelly Korzeniewski, research assistants in the UB Department of Medicine, all of the Division of Endocrinology, Diabetes and Metabolism of UB and Kaleida Health.

The study was supported by a grant from the Amylin Corporation and Eli-Lilly.


Story Source:

The above story is based on materials provided by University at Buffalo. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Chaudhuri, H. Ghanim, M. Vora, C. Ling Sia, K. Korzeniewski, S. Dhindsa, A. Makdissi, P. Dandona. Exenatide Exerts a Potent Antiinflammatory Effect. Journal of Clinical Endocrinology & Metabolism, 2011; DOI: 10.1210/jc.2011-1508

Cite This Page:

University at Buffalo. "Exenatide (Byetta) has rapid, powerful anti-inflammatory effect, study shows." ScienceDaily. ScienceDaily, 3 November 2011. <www.sciencedaily.com/releases/2011/11/111102125557.htm>.
University at Buffalo. (2011, November 3). Exenatide (Byetta) has rapid, powerful anti-inflammatory effect, study shows. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2011/11/111102125557.htm
University at Buffalo. "Exenatide (Byetta) has rapid, powerful anti-inflammatory effect, study shows." ScienceDaily. www.sciencedaily.com/releases/2011/11/111102125557.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins