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HDAC inhibitor may overcome resistance to common breast cancer drug

Date:
November 13, 2011
Source:
American Association for Cancer Research
Summary:
Researchers have shown how estrogen receptor-positive breast cancer tumors become resistant to tamoxifen, the only approved hormonal therapy for premenopausal patients with this type of breast cancer. They also found that introducing a novel histone deacetylase inhibitor in hormone therapy treatment can overcome resistance to hormonal therapy.

Researchers have shown how estrogen receptor-positive breast cancer tumors become resistant to tamoxifen, the only approved hormonal therapy for premenopausal patients with this type of breast cancer. They also found that introducing a novel histone deacetylase inhibitor in hormone therapy treatment can overcome resistance to hormonal therapy.

"We always thought that resistance was primarily an inborn or genetic effect," said Pamela N. Munster, M.D., director of the Early-Phase Clinical Trials Program at the University of California, San Francisco. "But this is not the case. Tumors have found a way to modify their genes to become resistant. This process is called 'epigenetics,' where genes are turned on and off, but the sequence of DNA is not altered. We have also found that with this kind of breast cancer, we can prevent that resistance with histone deacetylase (HDAC) inhibitors."

Munster presented the findings at the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, held Nov. 12-16, 2011.

She and her colleagues found that estrogen receptor (ER)-positive breast cancer tumors alter their genes to create more AKT, a protein that spurs actions within the cell to keep it alive -- the opposite of what tamoxifen is designed to do.

In a preclinical study, researchers introduced the HDAC inhibitor PCI-24781 at an early phase of tamoxifen treatment and found that it reverses the tumor's survival strategy of increasing production of AKT, thus stopping the tumor cells from developing resistance and leading to higher levels of cell death.

"The HDACs regulate the response of AKT to tamoxifen, and together, the effects of HDAC inhibitors and tamoxifen lead to more cell death if introduced with hormonal therapy," said Munster.

She added that previous attempts to reverse hormone resistance were made later in the course of hormonal therapy treatment, "and we think that introducing these approaches earlier may be more successful," she said.

The next step is to take this drug into clinical trials to investigate whether resistance to therapy can be prevented in patients with ER-positive breast cancer. A new look at AKT as a biomarker may help identify patients who are likely to benefit from this type of treatment.

This study was funded by the National Cancer Institute.


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The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


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American Association for Cancer Research. "HDAC inhibitor may overcome resistance to common breast cancer drug." ScienceDaily. ScienceDaily, 13 November 2011. <www.sciencedaily.com/releases/2011/11/111113141308.htm>.
American Association for Cancer Research. (2011, November 13). HDAC inhibitor may overcome resistance to common breast cancer drug. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2011/11/111113141308.htm
American Association for Cancer Research. "HDAC inhibitor may overcome resistance to common breast cancer drug." ScienceDaily. www.sciencedaily.com/releases/2011/11/111113141308.htm (accessed July 30, 2014).

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Tamoxifen Resistance -- And How to Defeat It

Nov. 13, 2011 In the last three decades, thousands of women with breast cancer have taken the drug tamoxifen, only to discover that the therapy doesn't work, either because their tumors do not respond to the ... read more
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