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The fat-burning zone: News on burning fat

Date:
November 17, 2011
Source:
University of Oslo
Summary:
Obesity-related diseases are an increasing health problem. Researchers have now uncovered a central component of fat metabolism.

Obesity-related diseases are an increasing health problem. Researchers at the University of Oslo have now uncovered a central component of fat metabolism.

It is well known that exercise results in "fat burning." Physical activity and fight-or-flight responses increase the levels of hormones like adrenaline, inducing the metabolism of fat. Until recently, some of the molecular details of exactly how this works have been a mystery.

Fats are stored inside fat cells within specialized compartments known as "lipid droplets" (LD), and their metabolism requires the cooperative action of several different proteins. Not only must these proteins act together, they must also be found within close physical proximity on the surface of the lipid droplets. This clustering of proteins is achieved by what are called anchoring proteins.

The essential role of the anchoring protein OPA1 in lipid metabolism was recently demonstrated by researchers in the Taskén group, and the study published in the EMBO Journal. Dr. Greenberg and colleagues from Harvard and Stanford University underlined on the importance of these findings in a research highlight: "The observation of [OPA1] on the LD surface provides an important step in understanding the regulation of LD biology.."

"It has taken a long time to sort this out." said Group Leader, Professor Kjetil Taskén. "In fact, the publication of this paper summarizes the work of two postdoctoral researchers and two PhD students over a period of more than seven years."


Story Source:

The above story is based on materials provided by University of Oslo. Note: Materials may be edited for content and length.


Journal References:

  1. Guillaume Pidoux, Oliwia Witczak, Elisabeth Jarnćss, Linda Myrvold, Henning Urlaub, Anne Jorunn Stokka, Thomas Küntziger, Kjetil Taskén. Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis. The EMBO Journal, 2011; 30 (21): 4371 DOI: 10.1038/emboj.2011.365
  2. Andrew S Greenberg, Fredric B Kraemer, Krishnakant G Soni, Mark P Jedrychowski, Qing-Wu Yan, Christine E Graham, Thomas A Bowman, Ayla Mansur. Lipid droplet meets a mitochondrial protein to regulate adipocyte lipolysis. The EMBO Journal, 2011; 30 (21): 4337 DOI: 10.1038/emboj.2011.371

Cite This Page:

University of Oslo. "The fat-burning zone: News on burning fat." ScienceDaily. ScienceDaily, 17 November 2011. <www.sciencedaily.com/releases/2011/11/111116103819.htm>.
University of Oslo. (2011, November 17). The fat-burning zone: News on burning fat. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2011/11/111116103819.htm
University of Oslo. "The fat-burning zone: News on burning fat." ScienceDaily. www.sciencedaily.com/releases/2011/11/111116103819.htm (accessed July 30, 2014).

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