Featured Research

from universities, journals, and other organizations

How the brain senses nutrient balance

Date:
January 23, 2012
Source:
Cell Press
Summary:
Now, a research study discovers intriguing new information about how dietary nutrients influence brain cells that are key regulators of energy balance in the body. The study suggests a cellular mechanism that may allow brain cells to translate different diets into different patterns of activity.

There is no doubt that eating a balanced diet is essential for maintaining a healthy body weight as well as appropriate arousal and energy balance, but the details about how the nutrients we consume are detected and processed in the brain remain elusive. Now, a research study discovers intriguing new information about how dietary nutrients influence brain cells that are key regulators of energy balance in the body.

The study, published by Cell Press in the November 17 issue of the journal Neuron, suggests a cellular mechanism that may allow brain cells to translate different diets into different patterns of activity.

"The nutritional composition of meals, such as the protein:carbohydrate (sugar) ratio has long been recognized to affect levels of arousal and attention," explains senior study author, Dr. Denis Burdakov, from the University of Cambridge. "However, while certain specialized neurons are known to sense individual nutrients, such as the sugar glucose, it remains unclear how typical dietary combinations of nutrients affect energy balance-regulating brain circuits."

Dr. Burdakov and colleagues studied how physiological mixtures of nutrients influenced "orexin/hypocretin" neurons, which are known to be critical regulators of wakefulness and energy balance in the body. Previous research had demonstrated that orexin/hypocretin neurons are inhibited by glucose. Surprisingly, the current study revealed that physiologically relevant mixtures of amino acids, the nutrients derived from proteins (such as egg white), stimulated and activated the orexin/hypocretin neurons. The researchers went on to show that when orexin/hypocretin neurons were simultaneously exposed to amino acids and sugars, the amino acids served to suppress the inhibitory influence of glucose.

Taken together, these results support a new and more complex nutrient-specific model for dietary regulation of orexin/hypocretin neurons. "We found that activity in the orexin/hypocretin system is regulated by macronutrient balance rather than simply by the caloric content of the diet, suggesting that the brain contains not only energy-sensing cells, but also cells that can measure dietary balance," concludes Dr Burdakov. "Our data support the idea that the orexin/hypocretin neurons are under a 'push-pull' control by sugars and proteins. Interestingly, although behavioral effects are beyond the scope of our study, this cellular model is consistent with reports that when compared with sugar-rich meals, protein-rich meals are more effective at promoting wakefulness and arousal."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. MaheshM. Karnani, John Apergis-Schoute, Antoine Adamantidis, LiseT. Jensen, Luis deLecea, Lars Fugger, Denis Burdakov. Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids. Neuron, 2011; 72 (4): 616 DOI: 10.1016/j.neuron.2011.08.027

Cite This Page:

Cell Press. "How the brain senses nutrient balance." ScienceDaily. ScienceDaily, 23 January 2012. <www.sciencedaily.com/releases/2011/11/111117140258.htm>.
Cell Press. (2012, January 23). How the brain senses nutrient balance. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2011/11/111117140258.htm
Cell Press. "How the brain senses nutrient balance." ScienceDaily. www.sciencedaily.com/releases/2011/11/111117140258.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins