Featured Research

from universities, journals, and other organizations

Extracellular matrix could lead to advances in regenerative medicine

Date:
January 5, 2012
Source:
National Physical Laboratory
Summary:
Scientists have created a functional model of the native extracellular matrix that provides structural support to cells to aid growth and proliferation. The model could lead to advances in regenerative medicine. The extracellular matrix provides the physical and chemical conditions that enable the development of all biological tissues. It is a complex nano-to-microscale structure made up of protein fibers and serves as a dynamic substrate that supports tissue repair and regeneration.

Atomic Force Microscopy (AFM) image of the designed extracellular matrix.
Credit: Image courtesy of National Physical Laboratory

NPL scientists have created a functional model of the native extracellular matrix which provides structural support to cells to aid growth and proliferation and could lead to advances in regenerative medicine.

The extracellular matrix (ECM) provides the physical and chemical conditions that enable the development of all biological tissues. It is a complex nano-to-microscale structure made up of protein fibres and serves as a dynamic substrate that supports tissue repair and regeneration.

Human-made structures designed to mimic and replace the native matrix in damaged or diseased tissues are highly sought after to advance our understanding of tissue organisation and to make regenerative medicine a reality.

Self-assembling peptide fibres that have similar properties to those of the native matrices are of particular interest. However, these near-crystalline nanostructures fail to arrange themselves into interconnected meshes at the microscopic scale, which is critical for bringing cells together and supporting tissue development.

To solve this problem, a research team at NPL designed a small protein consisting of two complementary domains (structural units) that promote the formation of highly branched networks of fibres that span microscopic dimensions. The team showed that the created matrix is very efficient in supporting cell attachment, growth and proliferation.

This research is part of the NPL-led international research project, 'Multiscale measurements in biophysical systems', which is jointly funded by NPL and the Scottish Universities Physics Alliance.

Read the full article detailing this research published in Angewandte Chemie -- the premier and most authoritative publication for critical advances in chemical research.


Story Source:

The above story is based on materials provided by National Physical Laboratory. Note: Materials may be edited for content and length.


Journal Reference:

  1. Angelo Bella, Santanu Ray, Michael Shaw, Maxim G. Ryadnov. Arbitrary Self-Assembly of Peptide Extracellular Microscopic Matrices. Angewandte Chemie International Edition, 2011; DOI: 10.1002/anie.201104647

Cite This Page:

National Physical Laboratory. "Extracellular matrix could lead to advances in regenerative medicine." ScienceDaily. ScienceDaily, 5 January 2012. <www.sciencedaily.com/releases/2011/12/111220102532.htm>.
National Physical Laboratory. (2012, January 5). Extracellular matrix could lead to advances in regenerative medicine. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2011/12/111220102532.htm
National Physical Laboratory. "Extracellular matrix could lead to advances in regenerative medicine." ScienceDaily. www.sciencedaily.com/releases/2011/12/111220102532.htm (accessed September 30, 2014).

Share This



More Matter & Energy News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Argentina's Tax Evaders Detected, Hunted Down by Drones

Argentina's Tax Evaders Detected, Hunted Down by Drones

AFP (Sep. 30, 2014) Argentina doesn't only have Lionel Messi the footballer, it has now also acquired "Mesi" the drone system which monitors undeclared mansions, swimming pools and soy fields to curb tax evasion in the country. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Do Video Games Trump Brain Training For Cognitive Boosts?

Do Video Games Trump Brain Training For Cognitive Boosts?

Newsy (Sep. 29, 2014) More and more studies are showing positive benefits to playing video games, but the jury is still out on brain training programs. Video provided by Newsy
Powered by NewsLook.com
CERN Celebrates 60 Years of Science

CERN Celebrates 60 Years of Science

Reuters - Business Video Online (Sep. 29, 2014) CERN, the European Organisation for Nuclear Research, celebrates 60 years of bringing nations together through science. As Joanna Partridge reports from inside the famous science centre it's also planning to turn the Large Hadron Collider particle accelerator back on after an upgrade. Video provided by Reuters
Powered by NewsLook.com
This 'Invisibility Cloak' Is Simpler Than Most

This 'Invisibility Cloak' Is Simpler Than Most

Newsy (Sep. 28, 2014) Researchers from the University of Rochester have created a type of invisibility cloak with simple focal lenses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins