Featured Research

from universities, journals, and other organizations

Extracellular matrix could lead to advances in regenerative medicine

Date:
January 5, 2012
Source:
National Physical Laboratory
Summary:
Scientists have created a functional model of the native extracellular matrix that provides structural support to cells to aid growth and proliferation. The model could lead to advances in regenerative medicine. The extracellular matrix provides the physical and chemical conditions that enable the development of all biological tissues. It is a complex nano-to-microscale structure made up of protein fibers and serves as a dynamic substrate that supports tissue repair and regeneration.

Atomic Force Microscopy (AFM) image of the designed extracellular matrix.
Credit: Image courtesy of National Physical Laboratory

NPL scientists have created a functional model of the native extracellular matrix which provides structural support to cells to aid growth and proliferation and could lead to advances in regenerative medicine.

The extracellular matrix (ECM) provides the physical and chemical conditions that enable the development of all biological tissues. It is a complex nano-to-microscale structure made up of protein fibres and serves as a dynamic substrate that supports tissue repair and regeneration.

Human-made structures designed to mimic and replace the native matrix in damaged or diseased tissues are highly sought after to advance our understanding of tissue organisation and to make regenerative medicine a reality.

Self-assembling peptide fibres that have similar properties to those of the native matrices are of particular interest. However, these near-crystalline nanostructures fail to arrange themselves into interconnected meshes at the microscopic scale, which is critical for bringing cells together and supporting tissue development.

To solve this problem, a research team at NPL designed a small protein consisting of two complementary domains (structural units) that promote the formation of highly branched networks of fibres that span microscopic dimensions. The team showed that the created matrix is very efficient in supporting cell attachment, growth and proliferation.

This research is part of the NPL-led international research project, 'Multiscale measurements in biophysical systems', which is jointly funded by NPL and the Scottish Universities Physics Alliance.

Read the full article detailing this research published in Angewandte Chemie -- the premier and most authoritative publication for critical advances in chemical research.


Story Source:

The above story is based on materials provided by National Physical Laboratory. Note: Materials may be edited for content and length.


Journal Reference:

  1. Angelo Bella, Santanu Ray, Michael Shaw, Maxim G. Ryadnov. Arbitrary Self-Assembly of Peptide Extracellular Microscopic Matrices. Angewandte Chemie International Edition, 2011; DOI: 10.1002/anie.201104647

Cite This Page:

National Physical Laboratory. "Extracellular matrix could lead to advances in regenerative medicine." ScienceDaily. ScienceDaily, 5 January 2012. <www.sciencedaily.com/releases/2011/12/111220102532.htm>.
National Physical Laboratory. (2012, January 5). Extracellular matrix could lead to advances in regenerative medicine. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2011/12/111220102532.htm
National Physical Laboratory. "Extracellular matrix could lead to advances in regenerative medicine." ScienceDaily. www.sciencedaily.com/releases/2011/12/111220102532.htm (accessed August 1, 2014).

Share This




More Matter & Energy News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Tesla, Panasonic Ink Deal To Make Huge Battery 'Gigafactory'

Tesla, Panasonic Ink Deal To Make Huge Battery 'Gigafactory'

Newsy (July 31, 2014) The deal will help build a massive battery factory that Tesla says will produce 500,000 lithium batteries by 2020. Video provided by Newsy
Powered by NewsLook.com
Britain Testing Driverless Cars on Roadways

Britain Testing Driverless Cars on Roadways

AP (July 30, 2014) British officials said on Wednesday that driverless cars will be tested on roads in as many as three cities in a trial program set to begin in January. Officials said the tests will last up to three years. (July 30) Video provided by AP
Powered by NewsLook.com
7 Ways to Use Toothpaste: Howdini Hacks

7 Ways to Use Toothpaste: Howdini Hacks

Howdini (July 30, 2014) Fresh breath and clean teeth are great, but have you ever thought, "my toothpaste could be doing more". Well, it can! Lots of things! Howdini has 7 new uses for this household staple. Video provided by Howdini
Powered by NewsLook.com
Smoked: 2015 Ducati Diavel Vs 2014 Chevy Corvette Stingray Drag Race

Smoked: 2015 Ducati Diavel Vs 2014 Chevy Corvette Stingray Drag Race

Cycle World (July 30, 2014) The Bonnier Motorcycle Group presents Smoked; a three part video series. In this episode the 2015 Ducati Diavel takes on the 2014 Chevy Corvette Stingray Video provided by Cycle World
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins