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Gene identified in increasing pancreatic cancer risk

Date:
December 31, 2011
Source:
American Association for Cancer Research
Summary:
Mutations in the ATM gene may increase the hereditary risk for pancreatic cancer, according to new research.
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Mutations in the ATM gene may increase the hereditary risk for pancreatic cancer, according to data published in Cancer Discovery, the newest journal of the American Association for Cancer Research.

Pancreatic cancer is one of the most morbid cancers, with less than 5 percent of those diagnosed with the disease surviving to five years. Approximately 10 percent of patients come from families with multiple cases of pancreatic cancer.

"There was significant reason to believe this clustering was due to genetics, but we had not, to this point, been able to find the causative genes that explained the cluster of pancreatic cancer for a majority of these families," said lead author Alison Klein, Ph.D., associate professor of oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and director of the National Familial Pancreas Tumor Registry.

Klein and colleagues used next-generation sequencing, including whole genome and whole exome analyses, and identified ATM gene mutations in two kindreds with familial pancreatic cancer.

When these initial findings were examined in a large series for patients, ATM mutations were present in four of 166 subjects with pancreatic cancer but were absent in 190 spousal control subsets.

Klein said that knowledge of the presence of the ATM gene could lead to better screening for pancreatic cancer, the fourth most common cause of cancer-related death. However, there are currently no recommended screening tests.

Many doctors use endoscopy as a screening tool for pancreatic cancer, but researchers are still evaluating this technique in clinical trials.


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The above post is reprinted from materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


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American Association for Cancer Research. "Gene identified in increasing pancreatic cancer risk." ScienceDaily. ScienceDaily, 31 December 2011. <www.sciencedaily.com/releases/2011/12/111229091834.htm>.
American Association for Cancer Research. (2011, December 31). Gene identified in increasing pancreatic cancer risk. ScienceDaily. Retrieved September 1, 2015 from www.sciencedaily.com/releases/2011/12/111229091834.htm
American Association for Cancer Research. "Gene identified in increasing pancreatic cancer risk." ScienceDaily. www.sciencedaily.com/releases/2011/12/111229091834.htm (accessed September 1, 2015).

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