Featured Research

from universities, journals, and other organizations

Intestinal worms may help promote healing

Date:
January 18, 2012
Source:
University of Medicine and Dentistry of New Jersey (UMDNJ)
Summary:
Intestinal worm infections may not be all bad, according to a new study. In research on mice immune reaction to the presence of intestinal worms was found to promote wound healing in the lungs.

Intestinal worm infections may not be all bad, according to a new study. In research on mice immune reaction to the presence of intestinal worms was found to promote wound healing in the lungs. The researchers have found cytokines that help oust intestinal worm infections in mice also soothe associated lung injury and inflammation. Cytokines are proteins released by cells that in turn play a role in communications among various cells in the body.

The new study has been published online in advance of print in Nature Medicine.

Many intestinal worms take a detour through the lungs en route to the gut. One such worm is Nippostrongylus brasiliensis, the equivalent in rodents to human hookworm, which currently infects over 700 million people worldwide. As this worm passes through the lungs, it induces tissue damage and inflammation.

To counter this assault, the body mobilizes a specific type of immune response called a Th2 response, which promotes expulsion of the worms. But the benefits of Th2 don't end there, according to the new research. Specific cell populations and immune proteins induced during a Th2 response to these parasites, including macrophages and interleukin (IL)-4 and -13, help to repair the worm-induced damage to the lungs. The parasite-induced Th2 response appears to activate multiple factors that are important in acute wound healing and control of inflammation, which together orchestrate an enhanced wound healing response. In mice unable to respond to these proteins, the researchers found that lung damage went unchecked.

Thus it is possible that promoting Th2 responses, triggered by parasites, may be beneficial in the treatment of wounds as well as acute lung injury caused by respiratory infections such as pneumonia.


Story Source:

The above story is based on materials provided by University of Medicine and Dentistry of New Jersey (UMDNJ). Note: Materials may be edited for content and length.


Journal Reference:

  1. Fei Chen, Zhugong Liu, Wenhui Wu, Cristina Rozo, Scott Bowdridge, Ariel Millman, Nico Van Rooijen, Joseph F Urban, Thomas A Wynn, William C Gause. An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection. Nature Medicine, 2012; DOI: 10.1038/nm.2628

Cite This Page:

University of Medicine and Dentistry of New Jersey (UMDNJ). "Intestinal worms may help promote healing." ScienceDaily. ScienceDaily, 18 January 2012. <www.sciencedaily.com/releases/2012/01/120110192721.htm>.
University of Medicine and Dentistry of New Jersey (UMDNJ). (2012, January 18). Intestinal worms may help promote healing. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2012/01/120110192721.htm
University of Medicine and Dentistry of New Jersey (UMDNJ). "Intestinal worms may help promote healing." ScienceDaily. www.sciencedaily.com/releases/2012/01/120110192721.htm (accessed July 26, 2014).

Share This




More Health & Medicine News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins