Featured Research

from universities, journals, and other organizations

Mutation drives viral sensors to initiate autoimmune disease

Date:
January 26, 2012
Source:
Cell Press
Summary:
A new study uses a mouse model of a human autoimmune disease to reveal how abnormal regulation of the intracellular sensors that detect invading viruses can lead to autoimmune pathology. The research provides key insight into mechanisms that underlie the development of autoimmune disease and may lead to more effective strategies for therapeutic intervention.

A new study uses a mouse model of a human autoimmune disease to reveal how abnormal regulation of the intracellular sensors that detect invading viruses can lead to autoimmune pathology. The research, published online on January 26th in the journal Immunity by Cell Press, provides key insight into mechanisms that underlie the development of autoimmune disease and may lead to more effective strategies for therapeutic intervention.

There are multiple intracellular sensors that detect viral infection by binding to viral nucleic acids (RNA and DNA). The majority of these receptors activate type I interferon (IFN) cytokines, which prevent viruses from copying themselves and facilitate appropriate antiviral immune responses. "The interferon response triggered by these sensors is important for protection against infection, but it must be carefully regulated to prevent inappropriate activation by the cells' own DNA and RNA," explains senior study author, Dr. Daniel B. Stetson from the Department of Immunology at the University of Washington School of Medicine.

In an earlier study, Dr. Stetson and colleagues identified an enzyme called Trex1 as an essential negative regulator of the antiviral response. Mutations that inactivate the gene for Trex1 have been linked with multiple IFN-associated human autoimmune diseases, including Aicardi-Goutieres syndrome (AGS). In the current study, the researchers used a Trex1-deficient mouse model of AGS to present a detailed step-wise characterization of the development of autoimmune disease. They identified the specific pathway linking DNA detection with IFN production and described how IFNs drive different aspects of the immune response.

"Together, our results provide an integrated picture of the development of autoimmune disease caused by Trex1 deficiency and a framework for understanding its progression," concludes Dr. Stetson. "Our findings have important implications for the development of therapies for IFN-associated human autoimmune diseases, such as systemic lupus erythematosus and AGS, a rare and severe disease that is currently untreatable and incurable."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alevtina Gall, Piper Treuting, KeithB. Elkon, Yueh-Ming Loo, Michael Gale, GlenN. Barber, DanielB. Stetson. Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease. Immunity, 2012; 36 (1): 120 DOI: 10.1016/j.immuni.2011.11.018

Cite This Page:

Cell Press. "Mutation drives viral sensors to initiate autoimmune disease." ScienceDaily. ScienceDaily, 26 January 2012. <www.sciencedaily.com/releases/2012/01/120126123657.htm>.
Cell Press. (2012, January 26). Mutation drives viral sensors to initiate autoimmune disease. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2012/01/120126123657.htm
Cell Press. "Mutation drives viral sensors to initiate autoimmune disease." ScienceDaily. www.sciencedaily.com/releases/2012/01/120126123657.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins