Featured Research

from universities, journals, and other organizations

Mutation drives viral sensors to initiate autoimmune disease

Date:
January 26, 2012
Source:
Cell Press
Summary:
A new study uses a mouse model of a human autoimmune disease to reveal how abnormal regulation of the intracellular sensors that detect invading viruses can lead to autoimmune pathology. The research provides key insight into mechanisms that underlie the development of autoimmune disease and may lead to more effective strategies for therapeutic intervention.

A new study uses a mouse model of a human autoimmune disease to reveal how abnormal regulation of the intracellular sensors that detect invading viruses can lead to autoimmune pathology. The research, published online on January 26th in the journal Immunity by Cell Press, provides key insight into mechanisms that underlie the development of autoimmune disease and may lead to more effective strategies for therapeutic intervention.

There are multiple intracellular sensors that detect viral infection by binding to viral nucleic acids (RNA and DNA). The majority of these receptors activate type I interferon (IFN) cytokines, which prevent viruses from copying themselves and facilitate appropriate antiviral immune responses. "The interferon response triggered by these sensors is important for protection against infection, but it must be carefully regulated to prevent inappropriate activation by the cells' own DNA and RNA," explains senior study author, Dr. Daniel B. Stetson from the Department of Immunology at the University of Washington School of Medicine.

In an earlier study, Dr. Stetson and colleagues identified an enzyme called Trex1 as an essential negative regulator of the antiviral response. Mutations that inactivate the gene for Trex1 have been linked with multiple IFN-associated human autoimmune diseases, including Aicardi-Goutieres syndrome (AGS). In the current study, the researchers used a Trex1-deficient mouse model of AGS to present a detailed step-wise characterization of the development of autoimmune disease. They identified the specific pathway linking DNA detection with IFN production and described how IFNs drive different aspects of the immune response.

"Together, our results provide an integrated picture of the development of autoimmune disease caused by Trex1 deficiency and a framework for understanding its progression," concludes Dr. Stetson. "Our findings have important implications for the development of therapies for IFN-associated human autoimmune diseases, such as systemic lupus erythematosus and AGS, a rare and severe disease that is currently untreatable and incurable."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alevtina Gall, Piper Treuting, KeithB. Elkon, Yueh-Ming Loo, Michael Gale, GlenN. Barber, DanielB. Stetson. Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease. Immunity, 2012; 36 (1): 120 DOI: 10.1016/j.immuni.2011.11.018

Cite This Page:

Cell Press. "Mutation drives viral sensors to initiate autoimmune disease." ScienceDaily. ScienceDaily, 26 January 2012. <www.sciencedaily.com/releases/2012/01/120126123657.htm>.
Cell Press. (2012, January 26). Mutation drives viral sensors to initiate autoimmune disease. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2012/01/120126123657.htm
Cell Press. "Mutation drives viral sensors to initiate autoimmune disease." ScienceDaily. www.sciencedaily.com/releases/2012/01/120126123657.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins