Featured Research

from universities, journals, and other organizations

Ovarian cancer risk related to inherited inflammation genes

Date:
February 7, 2012
Source:
H. Lee Moffitt Cancer Center & Research Institute
Summary:
Genes that are known to be involved in inflammation were found to be related to risk of ovarian cancer.

In a study conducted by researchers at Moffitt Cancer Center and colleagues from 11 other institutions in the Unites States and the United Kingdom, genes that are known to be involved in inflammation were found to be related to risk of ovarian cancer.

Related Articles


Their study appeared in a recent issue of Cancer Research, published by the American Association for Cancer Research.

Chronic inflammation is known to influence risk of several cancers, including ovarian cancer. The researchers identified 27 genes that are involved in inflammation and sought to determine whether inter-individual differences in these genes were related to risk of ovarian cancer. To do that they determined the frequency of 162 single-nucleotide polymorphisms (SNPs, pronounced "snips") in DNA extracted from a blood sample provided by approximately 900 women with ovarian cancer (cases) and 1000 cancer-free women (controls). Whenever a SNP is observed it means that there are two forms (alleles) of the gene and the least common one is termed the "minor allele." The frequency of 21 of the 162 SNPs differed between the cases and controls and was subsequently examined in a larger study that included 3,100 cases and 2,100 controls from five independent studies.

"When we examined the relationship between SNPs in inflammation-related genes and the risk of ovarian cancer, we found variants in five of the 27 genes were related to risk. What was interesting to us was that women who carried the minor alleles had lower ovarian cancer risk. Each SNP appeared to lower risk by about 10 percent," explained study co-author Thomas A. Sellers, Ph.D., M.P.H., Moffitt executive vice president and director of the Moffitt Research Institute.

One of the genes encodes Interleuken 1 alpha (IL1A), a cytokine, or a small signaling protein molecule that is involved in numerous immune and inflammatory responses, said the authors. IL1A has been associated with many inflammatory response conditions and diseases. In this study, the researchers found that IL1A, and another gene, AloX5, "appear to harbor common inherited variants associated with modest differences in the risk of ovarian cancer."

"The importance of inflammation pathways in the development of many cancers prompted us to examine this association between SNPS in inflammation-related genes and risk for ovarian cancer," explained Sellers. "If these results can be confirmed, it might provide insights into how risk may be reduced, through strategies to lower chronic inflammation."

The authors noted that in 2011 there were an estimated 225,500 new cases of ovarian cancer worldwide. Although some women are at greatly elevated risks of ovarian cancer due to inherited mutations in the BRCA1 and BRCA2 genes, these are rare in the population and account for perhaps 10 percent of cases. However, a substantial portion of genetic influence on ovarian cancer risk has been "unexplained" and some of that may be due to common genetic variants. Sellers points out that "the Il1A variant that was most strongly protective is carried by 30 percent of women in the study, so the impact at the population level is not trivial."

The Follow-Up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI) is funded by the National Cancer Institute and is based at Moffitt. In addition to researchers from Moffitt, researchers from Columbia University, Duke University, the Mayo Clinic College of Medicine, the University of South Florida, Brigham and Women's Hospital, the University of Cambridge (UK), the University of Southern California and the Institute of Cancer Research (UK) participated in the study.


Story Source:

The above story is based on materials provided by H. Lee Moffitt Cancer Center & Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. L. White, J. M. Schildkraut, R. T. Palmieri, E. S. Iversen, A. Berchuck, R. A. Vierkant, D. N. Rider, B. Charbonneau, M. S. Cicek, R. Sutphen, M. J. Birrer, P. D. P. Pharoah, H. Song, J. Tyrer, S. A. Gayther, S. J. Ramus, N. Wentzensen, H. P. Yang, M. Garcia-Closas, C. M. Phelan, J. M. Cunningham, B. L. Fridley, T. A. Sellers, E. L. Goode. Ovarian Cancer Risk Associated with Inherited Inflammation-Related Variants. Cancer Research, 2012; DOI: 10.1158/0008-5472.CAN-11-3512

Cite This Page:

H. Lee Moffitt Cancer Center & Research Institute. "Ovarian cancer risk related to inherited inflammation genes." ScienceDaily. ScienceDaily, 7 February 2012. <www.sciencedaily.com/releases/2012/02/120207133823.htm>.
H. Lee Moffitt Cancer Center & Research Institute. (2012, February 7). Ovarian cancer risk related to inherited inflammation genes. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2012/02/120207133823.htm
H. Lee Moffitt Cancer Center & Research Institute. "Ovarian cancer risk related to inherited inflammation genes." ScienceDaily. www.sciencedaily.com/releases/2012/02/120207133823.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com
British Navy Ship Arrives in Sierra Leone With Ebola Aid

British Navy Ship Arrives in Sierra Leone With Ebola Aid

AFP (Oct. 30, 2014) The British ship RFA ARGUS arrived in Sierra Leone to deliver supplies and equipment to help the fight against Ebola. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins