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Few genes control neuronal function

Date:
March 14, 2012
Source:
Linkoeping Universitet
Summary:
How are 100 billion cells created, each with specific duties? The human brain is evidence that nature can achieve this. Researchers have now taken a step closer to solving this mystery.

The magenta-colored structures are nerve cells that use odourant receptor 47b, which senses pheromones. Expression of this receptor is controlled by the transcription factor E93. When E93 is removed, the neurons lose their ability to fulfill their task do detect pheromones, as evidenced by the deactivation of the fluorescent proteins (image to the right). The glowing, green cells, that use olfactory receptor 92a, are not affected because they are controlled by other transcription factors.
Credit: Image courtesy of Linkoeping Universitet

How are 100 billion cells created, each with specific duties? The human brain is evidence that nature can achieve this. Researchers at Linkφping University in Sweden have now taken a step closer to solving this mystery.

"Knowledge about the mechanisms that diversify neurons and keep them diverse is necessary in order to cultivate and replace nerve cells in the future," says Mattias Alenius, Assistant Professor of Neuroscience, who has published his research breakthrough in the current issue of the journal PLoS Biology.

Alenius and his research team at the Department of Experimental and Clinical Medicine seek the answer to this pivotal question from a smaller perspective: the fruit fly's olfactory system.

The humble fly's olfactory system consists of 1200 olfactory neurons (humans have six million) divided into 34 groups. Each group responds to a particular set of odours, since all the neurons of the group use only one of the olfactory receptors present in the fly's antennas. Together, the receptors provide the fly with the ability to distinguish between thousands of odours: one olfactory receptor -- one neuron group, simple yet complex.

Alenius and his colleagues are the first to go through all of the fruit fly's 753 gene regulatory genes, called transcription factors. They have identified a set of seven that, in different combinations, are required to create each of the 34 neuron groups in the antenna. A surprising finding is that most transcription factors perform two tasks simultaneously: they can activate odorant receptors' expression; while at the same time turning off others in the same cell.

Alenius explains, "This is one of the many tricks that are useful to know for the future if you want to make and cultivate each of the many thousands of nerve cell groups that make up our brains."


Story Source:

The above story is based on materials provided by Linkoeping Universitet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shadi Jafari, Liza Alkhori, Alexander Schleiffer, Anna Brochtrup, Thomas Hummel, Mattias Alenius. Combinatorial Activation and Repression by Seven Transcription Factors Specify Drosophila Odorant Receptor Expression. PLoS Biology, 2012; 10 (3): e1001280 DOI: 10.1371/journal.pbio.1001280

Cite This Page:

Linkoeping Universitet. "Few genes control neuronal function." ScienceDaily. ScienceDaily, 14 March 2012. <www.sciencedaily.com/releases/2012/03/120314100429.htm>.
Linkoeping Universitet. (2012, March 14). Few genes control neuronal function. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2012/03/120314100429.htm
Linkoeping Universitet. "Few genes control neuronal function." ScienceDaily. www.sciencedaily.com/releases/2012/03/120314100429.htm (accessed April 20, 2014).

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