Featured Research

from universities, journals, and other organizations

Antibody therapy prevents gastrointestinal damage following radiation exposure in mice

Date:
April 4, 2012
Source:
Memorial Sloan-Kettering Cancer Center
Summary:
A new study offers the first evidence of a drug capable of preventing lethal damage to the gastrointestinal (GI) tract caused by exposure to high levels of ionizing radiation, such as those occurring during a nuclear incident. There are currently no FDA-approved treatments or prophylactics available to manage the condition, known as radiation gastrointestinal syndrome (RGS), which is associated with weight loss, vomiting, diarrhea, dehydration, systemic infection, and -- in extreme cases -- septic shock and death.

A new study offers the first evidence of a drug capable of preventing lethal damage to the gastrointestinal (GI) tract caused by exposure to high levels of ionizing radiation, such as those occurring during a nuclear incident. There are currently no FDA-approved treatments or prophylactics available to manage the condition, known as radiation gastrointestinal syndrome (RGS), which is associated with weight loss, vomiting, diarrhea, dehydration, systemic infection, and -- in extreme cases -- septic shock and death.

Related Articles


The research was conducted in mice by investigators at Memorial Sloan-Kettering Cancer Center and The University of Texas MD Anderson Cancer Center and will be published in the May 2012 issue of The Journal of Clinical Investigation.

The GI system is maintained through the continuous infusion of epithelial cells produced by specialized stem cells located in gland-like structures called crypts found in the epithelial lining of the small intestines and colon. High-dose irradiation kills these stem cells and destroys the protective epithelial barrier, or mucosa, resulting in onset of RGS within days of exposure.

According to the study, administration of a drug called 2A2 anti-ceramide antibody inhibited cell death (apoptosis) in blood vessels within the GI tract and improved 90-day survival from 0 percent to 80 percent among mice exposed to 15 Gy whole-body irradiation.

"We discovered that using this monoclonal antibody to inhibit blood vessel damage and dysfunction led to a dose-dependent increase in the number of surviving stem cells, which are highly active and responsible for repopulation of the damaged GI epithelium," said the study's corresponding author Richard N. Kolesnick, MD, a member of Memorial Sloan-Kettering's Molecular Pharmacology and Chemistry Program whose laboratory conducted the research experiments.

Developed by investigators at MD Anderson, the drug works by interfering with ceramide -- a lipid molecule that plays a role in apoptosis -- generated on the surface of the endothelial cells that make up the smallest blood vessels of a tumor.

The US Department of Health and Human Services has placed significant emphasis on the development and deployment of new therapies and countermeasures to protect first responders, military personnel, and others who are required to enter into areas of potential radiation contamination. Dr. Kolesnick and colleagues are working to develop anti-ceramide antibody as an agent used not only to protect against the damaging effects of radiation prior to exposure, but also to mitigate those effects after exposure.

The study was supported by the National Institutes of Health; Memorial Sloan-Kettering's Experimental Therapeutics Center, funded by William H. Goodwin and Alice Goodwin; the Virginia and D. K. Ludwig Fund for Cancer Research; AngelWorks; the Gilson-Longenbaugh Foundation; and the Marcus Foundation.


Story Source:

The above story is based on materials provided by Memorial Sloan-Kettering Cancer Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jimmy Rotolo, Branka Stancevic, Jianjun Zhang, Guoqiang Hua, John Fuller, Xianglei Yin, Adriana Haimovitz-Friedman, Kisu Kim, Ming Qian, Marina Cardσ-Vila, Zvi Fuks, Renata Pasqualini, Wadih Arap, Richard Kolesnick. Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice. Journal of Clinical Investigation, 2012; DOI: 10.1172/JCI59920

Cite This Page:

Memorial Sloan-Kettering Cancer Center. "Antibody therapy prevents gastrointestinal damage following radiation exposure in mice." ScienceDaily. ScienceDaily, 4 April 2012. <www.sciencedaily.com/releases/2012/04/120404161841.htm>.
Memorial Sloan-Kettering Cancer Center. (2012, April 4). Antibody therapy prevents gastrointestinal damage following radiation exposure in mice. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2012/04/120404161841.htm
Memorial Sloan-Kettering Cancer Center. "Antibody therapy prevents gastrointestinal damage following radiation exposure in mice." ScienceDaily. www.sciencedaily.com/releases/2012/04/120404161841.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Arthropod Fossil Might Be Relative Of Spiders, Scorpions

New Arthropod Fossil Might Be Relative Of Spiders, Scorpions

Newsy (Mar. 29, 2015) — A 508-million-year-old arthropod that swam in the Cambrian seas is thought to share a common ancestor with spiders and scorpions. Video provided by Newsy
Powered by NewsLook.com
Vietnam Rice Boom Piles Pressure on Farmers and the Environment

Vietnam Rice Boom Piles Pressure on Farmers and the Environment

AFP (Mar. 29, 2015) — Vietnam&apos;s drive to become the world&apos;s leading rice exporter is pushing farmers in the fertile Mekong Delta to the brink, say experts, with mounting costs to the environment. Duration: 02:35 Video provided by AFP
Powered by NewsLook.com
Raw: Lioness Has Rare Five-Cub Litter

Raw: Lioness Has Rare Five-Cub Litter

AP (Mar. 27, 2015) — A lioness in Pakistan has given birth to five cubs, twice the usual size of a litter. Queen gave birth to two other cubs just nine months ago. (March 27) Video provided by AP
Powered by NewsLook.com
Jockey Motion Tracking Reveals Racing Prowess

Jockey Motion Tracking Reveals Racing Prowess

Reuters - Innovations Video Online (Mar. 26, 2015) — Using motion tracking technology, researchers from the Royal Veterinary College (RVC) are trying to establish an optimum horse riding style to train junior jockeys, as well as enhance safety, health and well-being of both racehorses and jockeys. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins