Featured Research

from universities, journals, and other organizations

Division of labor in neural stem cell maintenance

Date:
April 24, 2012
Source:
University of Medicine and Dentistry of New Jersey (UMDNJ)
Summary:
Sibling growth factors cooperate to maintain a pool of neuron-generating stem cells in the brain, according to a new study.

Sibling growth factors cooperate to maintain a pool of neuron-generating stem cells in the brain, according to a study published in the journal Stem Cells by researchers at the University of Medicine and Dentistry of New Jersey (UMDNJ).

Numerous soluble proteins and receptors help to maintain neural stem cells' (NSCs) supportive environment in central nervous system (CNS). NSCs access some of these nurturing factors by sending cellular extensions into the cerebral spinal fluid (CSF), which is rich in stem cell-promoting proteins.

Insulin-like growth factors (IGF-I and IGF-II) are essential for the growth and development of the CNS. But although they are abundant in the brain and CSF, it was not clear whether they are required by NSCs. Steven Levison, PhD, and Teresa Wood, PhD, of UMDNJ-New Jersey Medical School and colleagues now show that IGF-I and -II cooperate to maintain NSC numbers and the NSCs' ability to self-renew. IGF-I maintains NSC numbers by promoting cell division (via the IGF-I receptor), whereas IGF-II drives the expression of proteins essential for NSC self-renewal and 'stemness' (via the insulin receptor).

The role of IGF-I and -II in maintaining NSC numbers and function might help to explain the cognitive impairments associated with aging, as the abundance of both proteins declines with age.

This study was funded by a Dean's grant from UMDNJ-New Jersey Medical School, NIH grants (R21HL094905, F31NS065607 and T32-HL069752) and a grant from the LeDucq Foundation.


Story Source:

The above story is based on materials provided by University of Medicine and Dentistry of New Jersey (UMDNJ). Note: Materials may be edited for content and length.


Journal Reference:

  1. Amber N. Ziegler, Joel S. Schneider, Mei Qin, William A. Tyler, John E Pintar, Diego Fraidenraich, Teresa L. Wood, Steven W. Levison. IGF-II Promotes Stemness of Neural Restricted Precursors. Stem Cells, 2012; DOI: 10.1002/stem.1095

Cite This Page:

University of Medicine and Dentistry of New Jersey (UMDNJ). "Division of labor in neural stem cell maintenance." ScienceDaily. ScienceDaily, 24 April 2012. <www.sciencedaily.com/releases/2012/04/120424162216.htm>.
University of Medicine and Dentistry of New Jersey (UMDNJ). (2012, April 24). Division of labor in neural stem cell maintenance. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2012/04/120424162216.htm
University of Medicine and Dentistry of New Jersey (UMDNJ). "Division of labor in neural stem cell maintenance." ScienceDaily. www.sciencedaily.com/releases/2012/04/120424162216.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins