Featured Research

from universities, journals, and other organizations

Resveratrol: Study resolves controversy on life-extending red wine ingredient, restores hope for anti-aging pill

Date:
May 1, 2012
Source:
Cell Press
Summary:
A new study appears to offer vindication for an approach to anti-aging drugs that has been at the center of heated scientific debate in recent years. The new findings show for the first time that the metabolic benefits of the red wine ingredient known as resveratrol evaporate in mice that lack the famed longevity gene SIRT1.

A study in the May issue of the Cell Press journal Cell Metabolism appears to offer vindication for an approach to anti-aging drugs that has been at the center of heated scientific debate in recent years. The new findings show for the first time that the metabolic benefits of the red wine ingredient known as resveratrol evaporate in mice that lack the famed longevity gene SIRT1.
Credit: © Mist / Fotolia

A study in the May issue of the Cell Press journal Cell Metabolism appears to offer vindication for an approach to anti-aging drugs that has been at the center of heated scientific debate in recent years. The new findings show for the first time that the metabolic benefits of the red wine ingredient known as resveratrol evaporate in mice that lack the famed longevity gene SIRT1.

"Resveratrol improves the health of mice on a high-fat diet and increases life span," said David Sinclair of Harvard Medical School. The question was how.

Resveratrol is a dirty molecule, he explained. Its benefits had been attributed largely to its actions on SIRT1, based on studies in yeast, worms, and flies, but the naturally occurring ingredient has other effects; it influences dozens of proteins, and some evidence had pointed to the importance of another well-known gene (called AMPK) for resveratrol's metabolic benefits. That called into question not only the biology, but also whether SIRT1-targeted drugs in development were aimed in the wrong direction. (Those doubts and other factors led the pharmaceutical company Sirtris to halt its last clinical trial of resveratrol last year.)

Answers were hard to come by in mice, because animals lacking SIRT1 altogether don't survive. Sinclair and his colleagues have now overcome that obstacle by producing mice in which the SIRT1 gene can be completely turned off in adults. They've discovered that those SIRT1-deficient adult mice don't enjoy the benefits of resveratrol.

The study also provides insight into another important aspect of the resveratrol controversy. Doubts had arisen in part because the red wine ingredient seems to act in different ways at different doses. The study by Sinclair and colleagues clears those details up, too.

They show that resveratrol targets SIRT1 directly at moderate doses and hits other targets at higher ones. Importantly, SIRT1 is required for resveratrol's benefits irrespective of dose. Based on the findings, Sinclair emphasizes the value of finding the lowest effective dose of resveratrol, and perhaps any drug, to avoid off-target effects.

George Vlasuk, CEO of Sirtris, who was not involved in the new study, says the findings in Cell Metabolism offer the "first definitive evidence" for a direct link between SIRT1 and the metabolic benefits of resveratrol.

"The work by Price et al. strongly supports the basic rationale being pursued at Sirtris, which focuses on the development of small-molecule compounds that directly activate the enzymatic activity of SIRT1 as a new therapeutic approach to many diseases of aging," Vlasuk wrote in an email.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nathan L. Price, Ana P. Gomes, Alvin J.Y. Ling, Filipe V. Duarte, Alejandro Martin-Montalvo, Brian J. North, Beamon Agarwal, Lan Ye, Giorgio Ramadori, Joao S. Teodoro, Basil P. Hubbard, Ana T. Varela, James G. Davis, Behzad Varamini, Angela Hafner, Ruin Moaddel, Anabela P. Rolo, Roberto Coppari, Carlos M. Palmeira, Rafael de Cabo, Joseph A. Baur, David A. Sinclair. SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function. Cell Metabolism, 2012; 15 (5): 675 DOI: 10.1016/j.cmet.2012.04.003

Cite This Page:

Cell Press. "Resveratrol: Study resolves controversy on life-extending red wine ingredient, restores hope for anti-aging pill." ScienceDaily. ScienceDaily, 1 May 2012. <www.sciencedaily.com/releases/2012/05/120501134209.htm>.
Cell Press. (2012, May 1). Resveratrol: Study resolves controversy on life-extending red wine ingredient, restores hope for anti-aging pill. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2012/05/120501134209.htm
Cell Press. "Resveratrol: Study resolves controversy on life-extending red wine ingredient, restores hope for anti-aging pill." ScienceDaily. www.sciencedaily.com/releases/2012/05/120501134209.htm (accessed July 25, 2014).

Share This




More Plants & Animals News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Boy Attacked by Shark in Florida

Boy Attacked by Shark in Florida

Reuters - US Online Video (July 24, 2014) — An 8-year-old boy is bitten in the leg by a shark while vacationing at a Florida beach. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Goma Cheese Brings Whiff of New Hope to DRC

Goma Cheese Brings Whiff of New Hope to DRC

Reuters - Business Video Online (July 24, 2014) — The eastern region of the Democratic Republic of Congo, mainly known for conflict and instability, is an unlikely place for the production of fine cheese. But a farm in the village of Masisi, in North Kivu is slowly transforming perceptions of the area. Known simply as Goma cheese, the Congolese version of Dutch gouda has gained popularity through out the region. Ciara Sutton reports. Video provided by Reuters
Powered by NewsLook.com
Tyrannosaur Pack-Hunting Theory Aided By New Footprints

Tyrannosaur Pack-Hunting Theory Aided By New Footprints

Newsy (July 24, 2014) — A new study claims a set of prehistoric T-Rex footprints supports the theory that the giant predators hunted in packs instead of alone. Video provided by Newsy
Powered by NewsLook.com
Dogs Appear To Become Jealous Of Owners' Attention

Dogs Appear To Become Jealous Of Owners' Attention

Newsy (July 23, 2014) — A U.C. San Diego researcher says jealousy isn't just a human trait, and dogs aren't the best at sharing the attention of humans with other dogs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

More Coverage


More Evidence for Longevity Pathway

May 1, 2012 — New research reinforces the claim that resveratrol -- a compound found in plants and food groups, notably red wine -- prolongs lifespan and health-span by interacting with key genes in mitochondria, ... read more
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins