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Dynamic changes in gene regulation in human stem cells revealed

Date:
May 3, 2012
Source:
The Scripps Research Institute
Summary:
A team led by scientists at The Scripps Research Institute and the University of California (UC) San Diego has discovered a new type of dynamic change in human stem cells.

A team led by scientists at The Scripps Research Institute and the University of California (UC) San Diego has discovered a new type of dynamic change in human stem cells. Last year, this team reported recurrent changes in the genomes of human pluripotent stem cells as they are expanded in culture. The current report, which appears in the May 4, 2012 issue of the journal Cell Stem Cell, shows that these cells can also change their epigenomes, the patterns of DNA modifications that regulate the activity of specific genes -- sometimes radically. These changes may influence the cells' abilities to serve as models of human disease and development.


Story Source:

The above story is based on materials provided by The Scripps Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kristopher L. Nazor, Gulsah Altun, Candace Lynch, Ha Tran, Julie V. Harness, Ileana Slavin, Ibon Garitaonandia, Franz-Josef Müller, Yu-Chieh Wang, Francesca S. Boscolo, Eyitayo Fakunle, Biljana Dumevska, Sunray Lee, Hyun Sook Park, Tsaiwei Olee, Darryl D. D'Lima, Ruslan Semechkin, Mana M. Parast, Vasiliy Galat, Andrew L. Laslett, Uli Schmidt, Hans S. Keirstead, Jeanne F. Loring, Louise C. Laurent. Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and Their Differentiated Derivatives. Cell Stem Cell, 2012; 10 (5): 620 DOI: 10.1016/j.stem.2012.02.013

Cite This Page:

The Scripps Research Institute. "Dynamic changes in gene regulation in human stem cells revealed." ScienceDaily. ScienceDaily, 3 May 2012. <www.sciencedaily.com/releases/2012/05/120503125718.htm>.
The Scripps Research Institute. (2012, May 3). Dynamic changes in gene regulation in human stem cells revealed. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2012/05/120503125718.htm
The Scripps Research Institute. "Dynamic changes in gene regulation in human stem cells revealed." ScienceDaily. www.sciencedaily.com/releases/2012/05/120503125718.htm (accessed April 19, 2014).

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