Featured Research

from universities, journals, and other organizations

Scientists discover new inflammatory target

Date:
May 9, 2012
Source:
Queen Mary, University of London
Summary:
Scientists have found a new role for the tiny organelles known as primary cilia - they are important for regulating inflammation.

Primary cilia.
Credit: Image courtesy of Queen Mary, University of London

Scientists from Queen Mary, University of London have found a new therapeutic target to combat inflammation.

The research, published in the journal Cellular and Molecular Life Sciences, revealed tiny organelles called primary cilia are important for regulating inflammation. The findings could lead to potential therapies for millions of people who suffer from arthritis.

Dr Martin Knight who led the research at Queen Mary's School of Engineering and Materials Science said: "Although primary cilia were discovered more than a century ago, we're only beginning to realise the importance they play in different diseases and conditions, and the potential therapeutic benefits that could be developed from manipulating cilia structure and function."

The researchers investigated the role of primary cilia in inflammation. They took cartilage cells and exposed them to a group of inflammatory proteins called cytokines, specifically interleukin-1 (IL-1), to see whether there were any changes to the primary cilia.

"When we exposed the cells to IL-1, in just three hours the primary cilia showed a 50 per cent increase in length," he said.

"But what was most interesting was when we treated cells to prevent this elongation of the cilium. The cartilage cells had a greatly reduced response to the inflammatory proteins and were therefore not as inflamed. This suggests a brand new therapeutic target for inflammation."

Co-author Dr Angus Wann, said this is the first time primary cilia have been suggested as a target for novel therapies to reduce the effects of inflammation.

"If we can work out how to better manipulate the primary cilium, we could potentially attenuate or even prevent inflammation," he said.

The research could also benefit others who suffer from illnesses which cause inflammation.


Story Source:

The above story is based on materials provided by Queen Mary, University of London. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. K. T. Wann, M. M. Knight. Primary cilia elongation in response to interleukin-1 mediates the inflammatory response. Cellular and Molecular Life Sciences, 2012; DOI: 10.1007/s00018-012-0980-y

Cite This Page:

Queen Mary, University of London. "Scientists discover new inflammatory target." ScienceDaily. ScienceDaily, 9 May 2012. <www.sciencedaily.com/releases/2012/05/120509111446.htm>.
Queen Mary, University of London. (2012, May 9). Scientists discover new inflammatory target. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2012/05/120509111446.htm
Queen Mary, University of London. "Scientists discover new inflammatory target." ScienceDaily. www.sciencedaily.com/releases/2012/05/120509111446.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins