Featured Research

from universities, journals, and other organizations

How high fat foods impact diabetes and metabolic syndrome

Date:
May 22, 2012
Source:
University of Michigan Health System
Summary:
The Bcl10 protein helps the free fatty acids found in high fat foods impair insulin action and raise blood sugar, new research shows.

A University of Michigan Health System study provides new clues about the health-damaging molecular changes set in motion by eating high-fat foods.

A better understanding of the body's response to indulgent eating could lead to new approaches for treating diabetes and metabolic syndrome. High-fat foods can contribute to obesity, which increases the risk for developing type 2 diabetes.

The researchers learned a key protein called Bcl10 is needed for the free fatty acids -- which are found in high fat food and stored in body fat -- to impair insulin action and lead to abnormally high blood sugar.

In the laboratory study, mice deficient in Bcl10 were protected from developing insulin resistance when fed a high-fat diet. The findings will be published May 31 in Cell Reports.

Insulin helps control blood sugar, but insulin resistance can lead to the abnormally high blood sugar levels that are the hallmark of diabetes. Insulin resistance can occur as part of metabolic syndrome, a cluster of conditions that increase the risk for type 2 diabetes and heart disease.

As millions of Americans become overweight and obese, type 2 diabetes and metabolic syndrome are on the rise.

"The study also underscores how very short-term changes in diet such as high-fat eating for only a few days, perhaps even less, can induce a state of insulin resistance," says senior study author Peter C. Lucas, M.D., Ph.D., associate professor of pathology at the University of Michigan Medical School.

Researchers began by investigating how free fatty acids induce inflammation and impair insulin action in the liver. It's thought the liver is a major target for the harmful effects of free fatty acids.

In the liver, free fatty acids undergo metabolism to produce diacylglycerols prior to inducing the inflammatory response. Diacylglycerols also activate NF-B signaling which has been linked with cancer, metabolic and vascular diseases.

The team of researchers concluded that Bcl10 is required for fatty acids to induce inflammation and insulin resistance. In the study, Bcl10-deficient mice showed significant improvement in regulation of blood sugar.

"We were surprised to learn that Bcl10, a protein previously known for its critical role in immune cell response to infection, also plays a critical role in the liver's response to fatty acid," says Lucas.. "This is an example of nature co-opting a mechanism fundamental to the immune system and using it in a metabolic organ, in this case, the liver."

"These findings reveal a new and important role for Bcl10 and could lead to novel ideas for treating patients with metabolic syndrome and type 2 diabetes," says co-senior author Linda M. McAllister-Lucas, M.D., Ph.D., associate professor of pediatric hemotology/oncology.


Story Source:

The above story is based on materials provided by University of Michigan Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. Matthew Van Beek, Katherine I. Oravecz-Wilson, Phillip C. Delekta, Shufang Gu, Xiangquan Li, Xiaohong Jin, Ingrid J. Apel, Katy S. Konkle, Yongjia Feng, Daniel H. Teitelbaum, Jürgen Ruland, Linda M. McAllister-Lucas, Peter C. Lucas. Bcl10 Links Saturated Fat Overnutrition with Hepatocellular NF-κB Activation and Insulin Resistance. Cell Reports, 2012; DOI: 10.1016/j.celrep.2012.04.006

Cite This Page:

University of Michigan Health System. "How high fat foods impact diabetes and metabolic syndrome." ScienceDaily. ScienceDaily, 22 May 2012. <www.sciencedaily.com/releases/2012/05/120522114536.htm>.
University of Michigan Health System. (2012, May 22). How high fat foods impact diabetes and metabolic syndrome. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2012/05/120522114536.htm
University of Michigan Health System. "How high fat foods impact diabetes and metabolic syndrome." ScienceDaily. www.sciencedaily.com/releases/2012/05/120522114536.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Predicting Heart Transplant Rejection With a Blood Test

Predicting Heart Transplant Rejection With a Blood Test

Ivanhoe (Aug. 27, 2014) — Now a new approach to rejection of donor organs could change the way doctors predict transplant rejection…without expensive, invasive procedures. Video provided by Ivanhoe
Powered by NewsLook.com
Better Braces That Vibrate

Better Braces That Vibrate

Ivanhoe (Aug. 27, 2014) — The length of time you have to keep your braces on could be cut in half thanks to a new device that speeds up the process. Video provided by Ivanhoe
Powered by NewsLook.com
Smartphone App Tracks Your Heart Rate

Smartphone App Tracks Your Heart Rate

Ivanhoe (Aug. 27, 2014) — A new app that can track your heart rate 24/7 is available for download in your app store and its convenience could save your life. Video provided by Ivanhoe
Powered by NewsLook.com
Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) — A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins