Featured Research

from universities, journals, and other organizations

Genetic discovery will help fight diarrhea outbreaks

Date:
June 14, 2012
Source:
University of East Anglia
Summary:
Researchers have discovered unexpectedly large genetic differences between two similar species of the pathogenic Cryptosporidium parasite.

Researchers at the University of East Anglia have discovered unexpectedly large genetic differences between two similar species of the pathogenic Cryptosporidium parasite.

Published June 14 in the journal Evolutionary Applications, the findings pave the way for a new gold standard test to distinguish between the waterborne parasite's two main species affecting humans. One species is spread from person to person (Cryptosporidium hominis) but the other is often spread from livestock to people (Cryptosporidium parvum).

"Being able to discriminate quickly between the two species means it is easier to spot an outbreak as it develops, trace the original source, and take appropriate urgent action to prevent further spread," said lead author Dr Kevin Tyler of Norwich Medical School at UEA.

Cryptosporidium is a protozoan parasite that causes outbreaks of diarrhea across the globe. In the UK, around two per cent of cases of diarrhea are caused by the organism and many people will be infected at some time in their lives. Symptoms include watery diarrhea, stomach pain, nausea and vomiting and can last for up to a month, but healthy people usually make a full recovery.

However, in the developing world infection can be serious in malnourished children and a significant cause of death in areas with high prevalence of untreated AIDS.

In the UK, outbreaks have been caused by faulty filtration systems in water supplies and transmission through swimming pools because the parasite is not killed by chlorine disinfection. Outbreaks also occur at open farms and in nurseries. People can also be infected by eating vegetables that have been washed in contaminated water. Hygiene is important in the prevention of spread of Cryptosporidium: people are advised to always wash their hands with warm running water and soap after touching animals, going to the toilet, changing nappies and before preparing, handling or eating food.

In this EU-funded study, the researchers identified the first parasite proteins that are specific to the different species. They found them at the ends of the chromosomes where they had been missed during previous parasite genetic studies.

Dr Tyler said: "Our discovery is an important advance in developing new simple and reliable tests for identifying these two species of parasite. This is the first step in discriminating outbreaks from sporadic cases, local strains from exotic ones, and tracing the source of outbreaks to an individual water supply, swimming pool or farm."


Story Source:

The above story is based on materials provided by University of East Anglia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Maha Bouzid, Paul R. Hunter, Vincent McDonald, Kristin Elwin, Rachel M. Chalmers, Kevin M. Tyler. A new heterogeneous family of telomerically encoded Cryptosporidium proteins. Evolutionary Applications, 2012; DOI: 10.1111/j.1752-4571.2012.00277.x

Cite This Page:

University of East Anglia. "Genetic discovery will help fight diarrhea outbreaks." ScienceDaily. ScienceDaily, 14 June 2012. <www.sciencedaily.com/releases/2012/06/120614082708.htm>.
University of East Anglia. (2012, June 14). Genetic discovery will help fight diarrhea outbreaks. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2012/06/120614082708.htm
University of East Anglia. "Genetic discovery will help fight diarrhea outbreaks." ScienceDaily. www.sciencedaily.com/releases/2012/06/120614082708.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins