Featured Research

from universities, journals, and other organizations

Genetic discovery will help fight diarrhea outbreaks

Date:
June 14, 2012
Source:
University of East Anglia
Summary:
Researchers have discovered unexpectedly large genetic differences between two similar species of the pathogenic Cryptosporidium parasite.

Researchers at the University of East Anglia have discovered unexpectedly large genetic differences between two similar species of the pathogenic Cryptosporidium parasite.

Published June 14 in the journal Evolutionary Applications, the findings pave the way for a new gold standard test to distinguish between the waterborne parasite's two main species affecting humans. One species is spread from person to person (Cryptosporidium hominis) but the other is often spread from livestock to people (Cryptosporidium parvum).

"Being able to discriminate quickly between the two species means it is easier to spot an outbreak as it develops, trace the original source, and take appropriate urgent action to prevent further spread," said lead author Dr Kevin Tyler of Norwich Medical School at UEA.

Cryptosporidium is a protozoan parasite that causes outbreaks of diarrhea across the globe. In the UK, around two per cent of cases of diarrhea are caused by the organism and many people will be infected at some time in their lives. Symptoms include watery diarrhea, stomach pain, nausea and vomiting and can last for up to a month, but healthy people usually make a full recovery.

However, in the developing world infection can be serious in malnourished children and a significant cause of death in areas with high prevalence of untreated AIDS.

In the UK, outbreaks have been caused by faulty filtration systems in water supplies and transmission through swimming pools because the parasite is not killed by chlorine disinfection. Outbreaks also occur at open farms and in nurseries. People can also be infected by eating vegetables that have been washed in contaminated water. Hygiene is important in the prevention of spread of Cryptosporidium: people are advised to always wash their hands with warm running water and soap after touching animals, going to the toilet, changing nappies and before preparing, handling or eating food.

In this EU-funded study, the researchers identified the first parasite proteins that are specific to the different species. They found them at the ends of the chromosomes where they had been missed during previous parasite genetic studies.

Dr Tyler said: "Our discovery is an important advance in developing new simple and reliable tests for identifying these two species of parasite. This is the first step in discriminating outbreaks from sporadic cases, local strains from exotic ones, and tracing the source of outbreaks to an individual water supply, swimming pool or farm."


Story Source:

The above story is based on materials provided by University of East Anglia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Maha Bouzid, Paul R. Hunter, Vincent McDonald, Kristin Elwin, Rachel M. Chalmers, Kevin M. Tyler. A new heterogeneous family of telomerically encoded Cryptosporidium proteins. Evolutionary Applications, 2012; DOI: 10.1111/j.1752-4571.2012.00277.x

Cite This Page:

University of East Anglia. "Genetic discovery will help fight diarrhea outbreaks." ScienceDaily. ScienceDaily, 14 June 2012. <www.sciencedaily.com/releases/2012/06/120614082708.htm>.
University of East Anglia. (2012, June 14). Genetic discovery will help fight diarrhea outbreaks. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2012/06/120614082708.htm
University of East Anglia. "Genetic discovery will help fight diarrhea outbreaks." ScienceDaily. www.sciencedaily.com/releases/2012/06/120614082708.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins