Featured Research

from universities, journals, and other organizations

Non-antibiotic approach for treating urinary tract infections

Date:
June 20, 2012
Source:
American Chemical Society
Summary:
A potential new approach for treating urinary tract infections -- which affect millions of people annually -- without traditional antibiotics has been developed. It involves so-called FimH antagonists, which are non-antibiotic compounds and would not contribute to the growing problem of antibiotic resistance bacteria.

Bacteria.
Credit: CDC

A potential new approach for treating urinary tract infections (UTIs) -- which affect millions of people annually -- without traditional antibiotics is being reported in ACS' Journal of Medicinal Chemistry. It involves so-called FimH antagonists, which are non-antibiotic compounds and would not contribute to the growing problem of antibiotic resistance bacteria.

Beat Ernst and colleagues explain that antibiotics are the mainstay treatment for UTIs. Bacteria, however, are developing resistance to common antibiotics, with the emergence of "superbugs" that shrug off some of the most powerful new antibiotics. Thus, the scientists decided to try a new approach -- developing substances that target bacteria virulence factors, inhibiting them from sticking to the inside of the urinary bladder. Hence, microbes are not able to launch an infection and, furthermore, this new class of antimicrobials is expected to exhibit less selection pressure and, therefore, a reduced potential for the emergence of resistance.

The scientists describe the development of anti-adhesion molecules that specifically interfere with the attachment of bacteria to human bladder cells. The most potent of the substances, an indolinylphenyl mannoside, prevented a UTI from developing in mice (stand-ins for humans in this kind of experiment) for more than eight hours. In the in vivo treatment study, a very low dose of 25 g per mouse reduced the amount of bacteria in the bladder of the animals by almost 10,000 times, which is comparable to the standard antibiotic treatment with ciprofloxacin.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Xiaohua Jiang, Daniela Abgottspon, Simon Kleeb, Said Rabbani, Meike Scharenberg, Matthias Wittwer, Martina Haug, Oliver Schwardt, Beat Ernst. Antiadhesion Therapy for Urinary Tract Infections—A Balanced PK/PD Profile Proved To Be Key for Success. Journal of Medicinal Chemistry, 2012; 55 (10): 4700 DOI: 10.1021/jm300192x

Cite This Page:

American Chemical Society. "Non-antibiotic approach for treating urinary tract infections." ScienceDaily. ScienceDaily, 20 June 2012. <www.sciencedaily.com/releases/2012/06/120620113338.htm>.
American Chemical Society. (2012, June 20). Non-antibiotic approach for treating urinary tract infections. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2012/06/120620113338.htm
American Chemical Society. "Non-antibiotic approach for treating urinary tract infections." ScienceDaily. www.sciencedaily.com/releases/2012/06/120620113338.htm (accessed April 24, 2014).

Share This



More Plants & Animals News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
Raw: Kangaroo Rescued from Swimming Pool

Raw: Kangaroo Rescued from Swimming Pool

AP (Apr. 24, 2014) A kangaroo was saved from drowning in a backyard suburban swimming pool in Australia's Victoria state on Thursday. Australian broadcaster Channel 7 showed footage of the kangaroo struggling to get out of the pool. (April 24) Video provided by AP
Powered by NewsLook.com
Could Marijuana Use Lead To Serious Heart Problems?

Could Marijuana Use Lead To Serious Heart Problems?

Newsy (Apr. 24, 2014) A new study says marijuana use could lead to serious heart-related complications. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins