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Non-antibiotic approach for treating urinary tract infections

Date:
June 20, 2012
Source:
American Chemical Society
Summary:
A potential new approach for treating urinary tract infections -- which affect millions of people annually -- without traditional antibiotics has been developed. It involves so-called FimH antagonists, which are non-antibiotic compounds and would not contribute to the growing problem of antibiotic resistance bacteria.
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Bacteria.
Credit: CDC

A potential new approach for treating urinary tract infections (UTIs) -- which affect millions of people annually -- without traditional antibiotics is being reported in ACS' Journal of Medicinal Chemistry. It involves so-called FimH antagonists, which are non-antibiotic compounds and would not contribute to the growing problem of antibiotic resistance bacteria.

Beat Ernst and colleagues explain that antibiotics are the mainstay treatment for UTIs. Bacteria, however, are developing resistance to common antibiotics, with the emergence of "superbugs" that shrug off some of the most powerful new antibiotics. Thus, the scientists decided to try a new approach -- developing substances that target bacteria virulence factors, inhibiting them from sticking to the inside of the urinary bladder. Hence, microbes are not able to launch an infection and, furthermore, this new class of antimicrobials is expected to exhibit less selection pressure and, therefore, a reduced potential for the emergence of resistance.

The scientists describe the development of anti-adhesion molecules that specifically interfere with the attachment of bacteria to human bladder cells. The most potent of the substances, an indolinylphenyl mannoside, prevented a UTI from developing in mice (stand-ins for humans in this kind of experiment) for more than eight hours. In the in vivo treatment study, a very low dose of 25 µg per mouse reduced the amount of bacteria in the bladder of the animals by almost 10,000 times, which is comparable to the standard antibiotic treatment with ciprofloxacin.


Story Source:

The above post is reprinted from materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Xiaohua Jiang, Daniela Abgottspon, Simon Kleeb, Said Rabbani, Meike Scharenberg, Matthias Wittwer, Martina Haug, Oliver Schwardt, Beat Ernst. Antiadhesion Therapy for Urinary Tract Infections—A Balanced PK/PD Profile Proved To Be Key for Success. Journal of Medicinal Chemistry, 2012; 55 (10): 4700 DOI: 10.1021/jm300192x

Cite This Page:

American Chemical Society. "Non-antibiotic approach for treating urinary tract infections." ScienceDaily. ScienceDaily, 20 June 2012. <www.sciencedaily.com/releases/2012/06/120620113338.htm>.
American Chemical Society. (2012, June 20). Non-antibiotic approach for treating urinary tract infections. ScienceDaily. Retrieved July 2, 2015 from www.sciencedaily.com/releases/2012/06/120620113338.htm
American Chemical Society. "Non-antibiotic approach for treating urinary tract infections." ScienceDaily. www.sciencedaily.com/releases/2012/06/120620113338.htm (accessed July 2, 2015).

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