Featured Research

from universities, journals, and other organizations

Giant raft of data to help us understand disease

Date:
June 28, 2012
Source:
University of Copenhagen
Summary:
Scientists have used a new method to assemble a massive catalog of data on proteins. This gives them unprecedented insight into a process called protein phosphorylation.

Scientists at the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen have used a new method to assemble a massive catalogue of data on proteins. This gives them unprecedented insight into a process called protein phosphorylation.

Related Articles


The research was recently published in the scientific journal Nature Communications.

Postdoc Alicia Lundby, from the Novo Nordisk Foundation Center for Protein Research, says: "Phosphorylation changes are really important to our understanding of cancer and other diseases. Although the study of phosphorylation goes back decades, up until now we hadn't been able to measure overall phosphorylation changes in tissue samples. Understanding these phosphorylation changes brings us a step closer to unraveling the mechanisms of disease."

Unraveling the mechanisms of disease

Phosphorylation happens when a phosphate group is added to a protein. Phosphorylation is like a switch that activates proteins, altering their function and changing cell signalling pathways. These signalling pathways are like cellular control panels. Deregulated cell signalling, when the control panel malfunctions, is a common hallmark of disease.

In the treatment of cancer, for example, there is great variation in how well the patients respond to different treatments. Most likely as a result of differences in the signalling pathways. The method developed by the team has the potential to make it possible to screen patient tissue samples to determine the best course of treatment for the individual.

An unprecedented resource

The team of scientists used high-resolution tandem mass spectrometry to generate the catalog of phosphorylated proteins. This research has never been attempted before on this scale -- 31,480 phosphorylation sites from 7,280 proteins in 14 different tissue types. From a scientific perspective, it offers an unprecedented resource that is available to biologists online.

"This dataset is like a big atlas that can be used by other scientists to benefit their research," says Alicia Lundby.

For their next project Alicia Lundby and colleagues will be investigating the beta-adrenergic pathway of the heart to gain insight into why the heart suddenly beats faster when adrenalin is released. It is hoped this will improve our understanding of the molecular impact of Beta-blockers, a widely prescribed medication for heart conditions.


Story Source:

The above story is based on materials provided by University of Copenhagen. Note: Materials may be edited for content and length.


Cite This Page:

University of Copenhagen. "Giant raft of data to help us understand disease." ScienceDaily. ScienceDaily, 28 June 2012. <www.sciencedaily.com/releases/2012/06/120628145632.htm>.
University of Copenhagen. (2012, June 28). Giant raft of data to help us understand disease. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2012/06/120628145632.htm
University of Copenhagen. "Giant raft of data to help us understand disease." ScienceDaily. www.sciencedaily.com/releases/2012/06/120628145632.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Feast Your Eyes: Lamb Chop Sent Into Space from UK

Feast Your Eyes: Lamb Chop Sent Into Space from UK

Reuters - Light News Video Online (Nov. 25, 2014) Take a stab at this -- stunt video shows a lamb chop's journey from an east London restaurant over 30 kilometers into space. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins