Featured Research

from universities, journals, and other organizations

Possible treatment to reduce scarring discovered

Date:
July 6, 2012
Source:
Federation of American Societies for Experimental Biology
Summary:
Ugly scars can affect body and mind, and new research offers a new strategy to reduce or eliminate scars on the skin. Scientists describe how agents that block receptors for adenosine (a molecule generated from ATP which is used by the body to provide energy to muscles) can be applied topically to healing wounds to reduce scar size, yielding skin that feels more like the original, unscarred skin.

Whether from surgery or battle wounds, ugly scars can affect body and mind. Now a new research report appearing online in the FASEB Journal offers a new strategy to reduce or eliminate scars on the skin. Specifically, scientists from NYU describe how agents that block receptors for adenosine (a molecule generated from ATP which is used by the body to provide energy to muscles) can be applied topically to healing wounds to reduce scar size, yielding skin that feels more like the original, unscarred skin.

Related Articles


"Scars can be disfiguring and, if extensive enough, can lead to diminished function and quality of life," said Bruce N. Cronstein, M.D., a researcher involved in the work from the Division of Translational Medicine in the Department of Medicine at New York University School of Medicine in New York, NY. "We hope that our findings may lead to new agents that diminish scarring and disfigurement following burns, wounds, or even illnesses that destroy skin and lead to a better quality of life for victims of these traumas."

When the skin or other tissues are wounded, ATP leaks from the damaged cells and is then converted to adenosine which promotes healing. Scars form when adenosine continues to be produced at the wound site after the injury is healed, leading to larger, thicker scars than what may have otherwise been there. To study the possibility of reducing scar sizes, Cronstein and colleagues studied wounds on the backs of mice. After the wound closed, the adenosine A2A receptor antagonist was applied. They found that the adenosine A2A receptor agonist prevented excessive scar tissue in the treated mice.

"The vast majority of scars are hardly noticeable, if they can be seen at all," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, "but for some, scars can severely disfigure not only the body, but the mind. Finding ways to prevent scarring after wounds or surgery has the potential to improve the quality of life for those who suffer the slings and arrows of outrageous fortune, now and for generations to come."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Perez-Aso, L. Chiriboga, B. N. Cronstein. Pharmacological blockade of adenosine A2A receptors diminishes scarring. The FASEB Journal, 2012; DOI: 10.1096/fj.12-209627

Cite This Page:

Federation of American Societies for Experimental Biology. "Possible treatment to reduce scarring discovered." ScienceDaily. ScienceDaily, 6 July 2012. <www.sciencedaily.com/releases/2012/07/120706164416.htm>.
Federation of American Societies for Experimental Biology. (2012, July 6). Possible treatment to reduce scarring discovered. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2012/07/120706164416.htm
Federation of American Societies for Experimental Biology. "Possible treatment to reduce scarring discovered." ScienceDaily. www.sciencedaily.com/releases/2012/07/120706164416.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins