Featured Research

from universities, journals, and other organizations

Regulation by proteins outside cancer cells points to potential new drug target: Reprogram cancer cells to state of permanent dormancy?

Date:
July 9, 2012
Source:
University of Texas Health Science Center at San Antonio
Summary:
Proteins outside cancer cells that send signals to the cancerous cells to stop proliferating represent a potential novel target for therapeutic strategy, says a biochemist whose team made the finding.

Protein interactions outside breast cancer cells can send signals to the cancer cells to permanently stop proliferating, a new study showed in the School of Medicine at The University of Texas Health Science Center San Antonio.

"Because this protein cascade is outside the cells, it is likely amenable to therapeutic manipulation," said lead author Yuzuru Shiio, M.D., Ph.D., assistant professor of biochemistry at the university's Greehey Children's Cancer Research Institute. "I hope our study will ultimately lead to a therapeutic strategy to reprogram cancer cells to a state of permanent dormancy."

He cautions that the finding was observed in cell cultures and is still far from human cancer therapy. Dr. Shiio is also a member of the Cancer Therapy & Research Center (CTRC) at the UT Health Science Center, a National Cancer Institute Designated Cancer Center.

Senescence is poorly understood

Upon successful chemotherapy, cancer cells either die or permanently stop proliferation. The latter phenomenon is called senescence and is poorly understood, Dr. Shiio said.

Using cultured breast cancer cells as a model, the team found that upon chemotherapeutic drug treatment these cells released factors that stop proliferation. By analyzing which proteins are released under this stress, the team discovered that a protein called IGFBP3 (insulin-like growth factor binding protein 3) is a key player in cancer senescence. The team then studied other proteins that work together with IGFBP3 outside of the cancer cells.

Needle in a haystack

Using powerful, large-scale analysis called proteomics, the researchers literally picked out the increased abundance of this one protein, IGFBP3, among a thousand other proteins outside of the cells. It was like finding a proverbial needle in a haystack.


Story Source:

The above story is based on materials provided by University of Texas Health Science Center at San Antonio. Note: Materials may be edited for content and length.


Journal Reference:

  1. David J. Elzi, Yanlai Lai, Meihua Song, Kevin Hakala, Susan T. Weintraub, and Yuzuru Shiio. Plasminogen activator inhibitor 1 - insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence. PNAS, July 9, 2012 DOI: 10.1073/pnas.1120437109

Cite This Page:

University of Texas Health Science Center at San Antonio. "Regulation by proteins outside cancer cells points to potential new drug target: Reprogram cancer cells to state of permanent dormancy?." ScienceDaily. ScienceDaily, 9 July 2012. <www.sciencedaily.com/releases/2012/07/120709155417.htm>.
University of Texas Health Science Center at San Antonio. (2012, July 9). Regulation by proteins outside cancer cells points to potential new drug target: Reprogram cancer cells to state of permanent dormancy?. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2012/07/120709155417.htm
University of Texas Health Science Center at San Antonio. "Regulation by proteins outside cancer cells points to potential new drug target: Reprogram cancer cells to state of permanent dormancy?." ScienceDaily. www.sciencedaily.com/releases/2012/07/120709155417.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins