Featured Research

from universities, journals, and other organizations

TLR1 protein drives immune response to certain food-borne illness in mice

Date:
July 10, 2012
Source:
University of Southern California - Health Sciences
Summary:
A naturally occurring protein called TLR1 plays a critical role in protecting the body from illnesses caused by eating undercooked pork or drinking contaminated water, according to new research.

A naturally occurring protein called TLR1 plays a critical role in protecting the body from illnesses caused by eating undercooked pork or drinking contaminated water, according to new research from the University of Southern California (USC).

Related Articles


The discovery may help create more effective oral vaccines for infections of the respiratory and gastrointestinal systems and already has launched an examination of how TLR1 is linked to inflammatory bowel disease, says R. William DePaolo, assistant professor of molecular microbiology and immunology at the Keck School of Medicine of USC and the study's lead investigator.

"It's not clear what drives the body's immune response," DePaolo said. "This paper identifies a receptor that is important in driving a mucosal immune response against Yersinia enterocolitica, bacteria like Salmonella and E. coli that can cause food poisoning. Although the receptor's role against other bacteria is still unknown, our research emphasizes that the way the body initiates an immune response depends on the pathogen and the route of infection."

The study, "A specific role for TLR1 in protective TH17 immunity during mucosal infection," is scheduled to appear in the July 30 edition of The Journal of Experimental Medicine.

DePaolo's team compared the immune responses of mice bred with and without TLR1 when infected with Y. enterocolitica by mouth and by blood. They found that TLR1 played a significant role in controlling mucosal infection (by mouth) but not systemic infection (by blood), initiating the creation of antibodies that specifically fight against oral infections.

"Now that we have identified the receptor's role, the next step is to determine how we can manipulate that receptor to enhance vaccine development," DePaolo said. "We also are studying the receptor in different models of mucosal inflammation including inflammatory bowel disease and colitis-associated cancers. The idea is to take a personalized approach to medicine and use genetic profiling to better treat or manage disease."


Story Source:

The above story is based on materials provided by University of Southern California - Health Sciences. The original article was written by Alison Trinidad. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. W. DePaolo, K. Kamdar, S. Khakpour, Y. Sugiura, W. Wang, B. Jabri. A specific role for TLR1 in protective TH17 immunity during mucosal infection. Journal of Experimental Medicine, 2012; DOI: 10.1084/jem.20112339

Cite This Page:

University of Southern California - Health Sciences. "TLR1 protein drives immune response to certain food-borne illness in mice." ScienceDaily. ScienceDaily, 10 July 2012. <www.sciencedaily.com/releases/2012/07/120710093947.htm>.
University of Southern California - Health Sciences. (2012, July 10). TLR1 protein drives immune response to certain food-borne illness in mice. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2012/07/120710093947.htm
University of Southern California - Health Sciences. "TLR1 protein drives immune response to certain food-borne illness in mice." ScienceDaily. www.sciencedaily.com/releases/2012/07/120710093947.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins