Featured Research

from universities, journals, and other organizations

NASA investigates proton radiation effects on cells

Date:
August 4, 2012
Source:
NASA
Summary:
A team of researchers has found radiation from protons could further enhance a process that occurs during tumor progression. This information may help lead to better methods to protect astronauts from the harmful effects of radiation in space, as well as help cancer researchers on Earth better understand the effects of radiation treatment on the human body.

A team of researchers at NASA's Johnson Space Center in Houston and Lawrence Berkeley National Laboratory in Berkeley, Calif., has found radiation from protons could further enhance a process that occurs during tumor progression. This information may help lead to better methods to protect astronauts from the harmful effects of radiation in space, as well as help cancer researchers on Earth better understand the effects of radiation treatment on the human body.

NASA is particularly interested in this research because protons, which are charged subatomic particles, are the main source of space radiation astronauts receive during spaceflights. The study was part of NASA's ongoing effort to learn how to mitigate the effects of radiation during long-duration missions to destinations beyond low Earth orbit, such as asteroids and Mars.

"Our paper makes new discoveries on the potential risks from low doses of protons that occur outside of the tumor during radiation therapy, and to all tissues for astronauts exposed to space radiation," said Francis A. Cucinotta, chief scientist for the Human Research Program Space Radiation Program Element at Johnson and one of the authors of the paper.

The objective of the researchers was to study the biological effects of low-energy protons on epithelial cells (membranous tissues found throughout the body) and the protons' propensity to enhance a process that occurs during tumor progression. This process is called epithelial-mesenchymal transition (EMT), which has been associated with cancer progression. EMT also has been linked to radiation-induced fibrosis, one of the most common late effects of radiotherapy.

Notably, the study revealed protons alone can induce EMT-associated changes in normal human epithelial cells. Although the total body dose received in space is moderately low compared to what is received in radiotherapy, this study reveals that low doses of protons still may prompt EMT and result in potentially detrimental effects.

These studies were conducted at Johnson and at the NASA Space Radiation Laboratory at Brookhaven National Laboratory, Upton, N.Y.

Results of the study were published as "Protons Sensitize Epithelial Cells to Mesenchymal Transition" in the July 23 issue of the journal PLoS ONE.


Story Source:

The above story is based on materials provided by NASA. Note: Materials may be edited for content and length.


Journal Reference:

  1. Minli Wang, Megumi Hada, Janapriya Saha, Deepa M. Sridharan, Janice M. Pluth, Francis A. Cucinotta. Protons Sensitize Epithelial Cells to Mesenchymal Transition. PLoS ONE, 2012; 7 (7): e41249 DOI: 10.1371/journal.pone.0041249

Cite This Page:

NASA. "NASA investigates proton radiation effects on cells." ScienceDaily. ScienceDaily, 4 August 2012. <www.sciencedaily.com/releases/2012/08/120804083925.htm>.
NASA. (2012, August 4). NASA investigates proton radiation effects on cells. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2012/08/120804083925.htm
NASA. "NASA investigates proton radiation effects on cells." ScienceDaily. www.sciencedaily.com/releases/2012/08/120804083925.htm (accessed July 22, 2014).

Share This




More Space & Time News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Neil Armstrong's Post-Apollo 11 Life

Neil Armstrong's Post-Apollo 11 Life

Newsy (July 19, 2014) Neil Armstrong gained international fame after becoming the first man to walk on the moon in 1969. But what was his life like after the historic trip? Video provided by Newsy
Powered by NewsLook.com
This Week @ NASA, July 18, 2014

This Week @ NASA, July 18, 2014

NASA (July 18, 2014) Apollo 11 yesterday, Next Giant Leap tomorrow, Science instruments for Europa mission, and more... Video provided by NASA
Powered by NewsLook.com
45 Years Later, Buzz Aldrin on Walking on Moon

45 Years Later, Buzz Aldrin on Walking on Moon

AP (July 18, 2014) Forty-five years ago Sunday, Apollo 11's Neil Armstrong and Buzz Aldrin became the first humans to set foot on the moon. Speaking at the Intrepid Sea, Air & Space Museum, Aldrin described what he was thinking right before the historic walk. (July 18) Video provided by AP
Powered by NewsLook.com
Orbital Cargo Ship Reaches International Space Station

Orbital Cargo Ship Reaches International Space Station

AFP (July 16, 2014) Orbital Sciences Corporation's unmanned cargo ship arrived Wednesday at the International Space Station carrying a load of food and equipment for the six-man crew at the research outpost. Duration: 00:33 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins