Featured Research

from universities, journals, and other organizations

Why do infants get sick so often? Cell signaling prevents growth of essential immune cells, study shows

Date:
August 7, 2012
Source:
University of Michigan Health System
Summary:
Babies can get sick often, but parents shouldn't take the blame. A new study shows essential immune cells that help fight infections don't develop until adulthood.

Researchers are helping to quell parents' worry about why infants seem to get sick so often.
Credit: Yuri Arcurs / Fotolia

Researchers at the University of Michigan Health System are helping to quell parents' worry about why infants seem to get sick so often.

It's been believed that, like walking and talking, fighting viral infections is something children will develop when they get older. But a U-M study suggests the natural ability to fight infection is there early on.

Scientists learned key cell signals inhibit the growth of essential immune cells early in life. Blocking this signaling could lead to improving an infant's response to infection, according to the study published online ahead of print in Nature Immunity.

"What happens at early age is that natural killer cells, like many other immune cells, do not complete their functional maturation until adulthood," says study senior author Yasmina Laouar, Ph.D., assistant professor in the U-M Department of Microbiology and Immunology.

"During this time we are left with an immature immune system that cannot protect us against infections, the reason why newborns and infants are more prone to infection," she says.

There is a large gap in understanding infant immunity, specifically why the natural killer cell responses are deficient. The study by immunologists at the U-M demonstrates the role of a cell called transforming growth factor beta that can explain why.

The study showed the production of natural killer cells is controlled by TGF-β, which is produced in the bone marrow. In infant mice, the maturation of natural killer cells progressed faster in the absence of TGF-β signaling.

By adulthood, mice had 10 times more mature natural killer cells if TGF-β signaling was blocked.

"Our overall goal was to determine the factors that constraint the production and maturation of natural killer cells early in life," says Laouar. "To our surprise, we discovered that natural killer cells can complete maturation as early as 10 days of age if TGF-β signaling is blocked."

Authors say it's tempting to propose the functional inactivation TGF-β signaling as a strategy to reverse the deficit of natural killer cells early in life. Additional testing will be required.


Story Source:

The above story is based on materials provided by University of Michigan Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jeffrey P Marcoe, James R Lim, Keri L Schaubert, Nassima Fodil-Cornu, Marsel Matka, Alexandra L McCubbrey, Alexander R Farr, Silvia M Vidal, Yasmina Laouar. TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy. Nature Immunology, 2012; DOI: 10.1038/ni.2388

Cite This Page:

University of Michigan Health System. "Why do infants get sick so often? Cell signaling prevents growth of essential immune cells, study shows." ScienceDaily. ScienceDaily, 7 August 2012. <www.sciencedaily.com/releases/2012/08/120807101334.htm>.
University of Michigan Health System. (2012, August 7). Why do infants get sick so often? Cell signaling prevents growth of essential immune cells, study shows. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2012/08/120807101334.htm
University of Michigan Health System. "Why do infants get sick so often? Cell signaling prevents growth of essential immune cells, study shows." ScienceDaily. www.sciencedaily.com/releases/2012/08/120807101334.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
American Ebola Patient Apparently Improving, Outbreak Is Not

American Ebola Patient Apparently Improving, Outbreak Is Not

Newsy (Aug. 19, 2014) Nancy Writebol, an American missionary who contracted Ebola, is apparently getting better, according to her husband. The outbreak, however, is not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins