Featured Research

from universities, journals, and other organizations

Ovarian cancer cells hijack surrounding tissues to enhance tumor growth

Date:
September 4, 2012
Source:
Journal of Clinical Investigation
Summary:
Researchers have discovered that ovarian cancer cells activate the HOXA9 gene to compel stromal cells to create an environment that supports tumor growth.

Tumor growth is dependent on interactions between cancer cells and adjacent normal tissue, or stroma. Stromal cells can stimulate the growth of tumor cells; however it is unclear if tumor cells can influence the stroma.

In the September issue of the Journal of Clinical Investigation, researchers at MD Anderson Cancer Center report that ovarian cancer cells activate the HOXA9 gene to compel stromal cells to create an environment that supports tumor growth.

Honami Naora and colleagues found that expression of HOXA9 was correlated with poor outcomes in cancer patients and in mice with ovarian tumors. The expression of HOXA9 in ovarian cancer cells caused the cells to produce a protein called TGF-β. TGF-β then induced the surrounding non-cancerous cells to create an environment that supports the tumor. Blocking TGF-β expression in the ovarian cancer cells significantly reduced tumor growth.

These findings raise the possibility that drugs targeting TGF-β could be used to treat ovarian cancer.

The research is published in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Song Yi Ko, Nicolas Barengo, Andras Ladanyi, Ju-Seog Lee, Frank Marini, Ernst Lengyel, Honami Naora. HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts. Journal of Clinical Investigation, 2012; DOI: 10.1172/JCI62229

Cite This Page:

Journal of Clinical Investigation. "Ovarian cancer cells hijack surrounding tissues to enhance tumor growth." ScienceDaily. ScienceDaily, 4 September 2012. <www.sciencedaily.com/releases/2012/09/120904121436.htm>.
Journal of Clinical Investigation. (2012, September 4). Ovarian cancer cells hijack surrounding tissues to enhance tumor growth. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2012/09/120904121436.htm
Journal of Clinical Investigation. "Ovarian cancer cells hijack surrounding tissues to enhance tumor growth." ScienceDaily. www.sciencedaily.com/releases/2012/09/120904121436.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins