Featured Research

from universities, journals, and other organizations

Ovarian cancer cells hijack surrounding tissues to enhance tumor growth

Date:
September 4, 2012
Source:
Journal of Clinical Investigation
Summary:
Researchers have discovered that ovarian cancer cells activate the HOXA9 gene to compel stromal cells to create an environment that supports tumor growth.

Tumor growth is dependent on interactions between cancer cells and adjacent normal tissue, or stroma. Stromal cells can stimulate the growth of tumor cells; however it is unclear if tumor cells can influence the stroma.

Related Articles


In the September issue of the Journal of Clinical Investigation, researchers at MD Anderson Cancer Center report that ovarian cancer cells activate the HOXA9 gene to compel stromal cells to create an environment that supports tumor growth.

Honami Naora and colleagues found that expression of HOXA9 was correlated with poor outcomes in cancer patients and in mice with ovarian tumors. The expression of HOXA9 in ovarian cancer cells caused the cells to produce a protein called TGF-β. TGF-β then induced the surrounding non-cancerous cells to create an environment that supports the tumor. Blocking TGF-β expression in the ovarian cancer cells significantly reduced tumor growth.

These findings raise the possibility that drugs targeting TGF-β could be used to treat ovarian cancer.

The research is published in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Song Yi Ko, Nicolas Barengo, Andras Ladanyi, Ju-Seog Lee, Frank Marini, Ernst Lengyel, Honami Naora. HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts. Journal of Clinical Investigation, 2012; DOI: 10.1172/JCI62229

Cite This Page:

Journal of Clinical Investigation. "Ovarian cancer cells hijack surrounding tissues to enhance tumor growth." ScienceDaily. ScienceDaily, 4 September 2012. <www.sciencedaily.com/releases/2012/09/120904121436.htm>.
Journal of Clinical Investigation. (2012, September 4). Ovarian cancer cells hijack surrounding tissues to enhance tumor growth. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2012/09/120904121436.htm
Journal of Clinical Investigation. "Ovarian cancer cells hijack surrounding tissues to enhance tumor growth." ScienceDaily. www.sciencedaily.com/releases/2012/09/120904121436.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins